1. PROTAC
  2. Ligand for E3 Ligase
  3. E3 ligase Ligand 1 dihydrochloride

E3 ligase Ligand 1 dihydrochloride 

Cat. No.: HY-42424A Purity: 98.19% ee.: 99.98%
Handling Instructions

E3 ligase Ligand 1 dihydrochloride is a von Hippel-Landau (VHL) E3 ligase-binding moiety based on PROTAC technology.

For research use only. We do not sell to patients.

E3 ligase Ligand 1 dihydrochloride Chemical Structure

E3 ligase Ligand 1 dihydrochloride Chemical Structure

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 330 In-stock
Estimated Time of Arrival: December 31
100 mg USD 300 In-stock
Estimated Time of Arrival: December 31
500 mg USD 650 In-stock
Estimated Time of Arrival: December 31
1 g USD 1000 In-stock
Estimated Time of Arrival: December 31
2 g USD 1800 In-stock
Estimated Time of Arrival: December 31
5 g   Get quote  
10 g   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of E3 ligase Ligand 1 dihydrochloride:

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Description

E3 ligase Ligand 1 dihydrochloride is a von Hippel-Landau (VHL) E3 ligase-binding moiety based on PROTAC technology.

In Vitro

E3 ligase Ligand 1 dihydrochloride is a von Hippel-Landau (VHL) E3 ligase-binding moiety based on PROTAC technology. E3 ligase Ligand 1 is a part of the active BRD4 PROTAC ARV-771, wich is a potent pan-BET degrader with antitumor activity[1].

Molecular Weight

517.51

Formula

C₂₃H₃₄Cl₂N₄O₃S

SMILES

N[[email protected]@H](C(C)(C)C)C(N1[[email protected]](C(N[[email protected]@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[[email protected]@H](O)C1)=O.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (193.23 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9323 mL 9.6616 mL 19.3233 mL
5 mM 0.3865 mL 1.9323 mL 3.8647 mL
10 mM 0.1932 mL 0.9662 mL 1.9323 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
E3 ligase Ligand 1 dihydrochloride
Cat. No.:
HY-42424A
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