VH 101, acid
Based on 1 Customer Validation
VH 101, acid is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development. VH 101, acid contains an E3 ligase ligand plus an alkyl linker with terminal amine ready for conjugation to a target protein ligand.
For research use only. We do not sell to patients.
- Purity: 98.82%
- CAS No.: 2408341-97-7
- Formula: C28H35FN4O6S
- Molecular Weight:574.66
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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VHL |
The VHL protein is a substrate recognition subunit of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. VHL is one of the most popular E3 ligases being recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a target protein[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2408341-97-7
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Appearance Solid
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Molecular Weight 574.66
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Formula C28H35FN4O6S
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Color White to off-white
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SMILES
O=C(C1(CC1)F)N[C@@H](C(C)(C)C)C(N2[C@@H](C[C@H](C2)O)C(N[C@H](C3=CC=C(C4=C(N=CS4)C)C=C3)CC(O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL (174.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7402 mL | 8.7008 mL | 17.4016 mL | 43.5040 mL |
| 5 mM | 0.3480 mL | 1.7402 mL | 3.4803 mL | 8.7008 mL | |
| 10 mM | 0.1740 mL | 0.8701 mL | 1.7402 mL | 4.3504 mL | |
| 15 mM | 0.1160 mL | 0.5801 mL | 1.1601 mL | 2.9003 mL | |
| 20 mM | 0.0870 mL | 0.4350 mL | 0.8701 mL | 2.1752 mL | |
| 25 mM | 0.0696 mL | 0.3480 mL | 0.6961 mL | 1.7402 mL | |
| 30 mM | 0.0580 mL | 0.2900 mL | 0.5801 mL | 1.4501 mL | |
| 40 mM | 0.0435 mL | 0.2175 mL | 0.4350 mL | 1.0876 mL | |
| 50 mM | 0.0348 mL | 0.1740 mL | 0.3480 mL | 0.8701 mL | |
| 60 mM | 0.0290 mL | 0.1450 mL | 0.2900 mL | 0.7251 mL | |
| 80 mM | 0.0218 mL | 0.1088 mL | 0.2175 mL | 0.5438 mL | |
| 100 mM | 0.0174 mL | 0.0870 mL | 0.1740 mL | 0.4350 mL |
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