1. Epigenetics
  2. Epigenetic Reader Domain
  3. dTRIM24


Cat. No.: HY-111519 Purity: 98.20%
Handling Instructions

dTRIM24 is a selective bifunctional degrader of TRIM24 based on PROTAC.

For research use only. We do not sell to patients.

dTRIM24 Chemical Structure

dTRIM24 Chemical Structure

CAS No. : 2170695-14-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 674 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2450 In-stock
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100 mg USD 4200 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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dTRIM24 is a selective bifunctional degrader of TRIM24 based on PROTAC.

IC50 & Target


In Vitro

dTRIM24 is a degrader of TRIM24 bromodomain. Recruitment of the VHL E3 ubiquitin ligase by dTRIM24 elicits potent and selective degradation of TRIM24. The anti-proliferative consequences of chemical degradation versus inhibition of TRIM24 are assessed. Growth over time is determined for MOLM-13 cells treated with dTRIM24, IACS-9571, VL-269, and eTRIM24. dTRIM24 suppresses growth to a greater extent than does IACS-9571, accompanied by apoptosis measured as enhanced PARP cleavage. In agreement with a sustained proliferative defect observed following dTRIM24 treatment, near-complete degradation of TRIM24 is observed in dTRIM24-treated cells throughout the duration of the experiment[2].

Molecular Weight







CN(C(N1C)=O)C2=C1C=C(OC3=CC=CC(OCCC)=C3)C(NS(C4=CC(C(NCCOCCOCCOCC(N[[email protected]](C(N5[[email protected]](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[[email protected]@H](O)C5)=O)C(C)(C)C)=O)=O)=CC=C4)(=O)=O)=C2


Room temperature in continental US; may vary elsewhere

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : < 1 mg/mL (insoluble)

Cell Assay

MOLM-13 cells are seeded at 30,000 cells/well. Growth over time of MOLM-13 cells treated with 5 μM of indicated compounds (e.g., dTRIM24) over 7 d. At endpoints, cells are suspended and mixed with Viacount reagent at 1:3. The mixture is incubated for 5 min, and viable cells are counted on the Guava easycyte flow cytometer. Means from three technical replicates of cell counts are calculated[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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