1. Epigenetics
  2. Epigenetic Reader Domain

dTRIM24 

Cat. No.: HY-111519
Handling Instructions

dTRIM24 is a selective bifunctional degrader of TRIM24.

For research use only. We do not sell to patients.

dTRIM24 Chemical Structure

dTRIM24 Chemical Structure

CAS No. : 2170695-14-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 674 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2750 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

dTRIM24 is a selective bifunctional degrader of TRIM24.

IC50 & Target

TRIM24[2].

In Vitro

dTRIM24 is a degrader of TRIM24 bromodomain. Recruitment of the VHL E3 ubiquitin ligase by dTRIM24 elicits potent and selective degradation of TRIM24. The anti-proliferative consequences of chemical degradation versus inhibition of TRIM24 are assessed. Growth over time is determined for MOLM-13 cells treated with dTRIM24, IACS-9571, VL-269, and eTRIM24. dTRIM24 suppresses growth to a greater extent than does IACS-9571, accompanied by apoptosis measured as enhanced PARP cleavage. In agreement with a sustained proliferative defect observed following dTRIM24 treatment, near-complete degradation of TRIM24 is observed in dTRIM24-treated cells throughout the duration of the experiment[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8982 mL 4.4912 mL 8.9823 mL
5 mM 0.1796 mL 0.8982 mL 1.7965 mL
10 mM 0.0898 mL 0.4491 mL 0.8982 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[2]

MOLM-13 cells are seeded at 30,000 cells/well. Growth over time of MOLM-13 cells treated with 5 μM of indicated compounds (e.g., dTRIM24) over 7 d. At endpoints, cells are suspended and mixed with Viacount reagent at 1:3. The mixture is incubated for 5 min, and viable cells are counted on the Guava easycyte flow cytometer. Means from three technical replicates of cell counts are calculated[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

1113.30

Formula

C₅₅H₆₈N₈O₁₃S₂

CAS No.

2170695-14-2

SMILES

CN(C(N1C)=O)C2=C1C=C(OC3=CC=CC(OCCC)=C3)C(NS(C4=CC(C(NCCOCCOCCOCC(N[[email protected]](C(N5[[email protected]](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[[email protected]@H](O)C5)=O)C(C)(C)C)=O)=O)=CC=C4)(=O)=O)=C2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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dTRIM24
Cat. No.:
HY-111519
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dTRIM24

Cat. No.: HY-111519