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PROTAC CRBN Degrader-1 

Cat. No.: HY-128845 Purity: 99.34%
Handling Instructions

PROTAC CRBN Degrader-1 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group. PROTAC CRBN Degrader-1 is an cereblon (CRBN) degrader.

For research use only. We do not sell to patients.

PROTAC CRBN Degrader-1 Chemical Structure

PROTAC CRBN Degrader-1 Chemical Structure

CAS No. : 2358775-70-7

Size Price Stock Quantity
1 mg USD 320 In-stock
Estimated Time of Arrival: December 31
5 mg USD 950 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
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Description

PROTAC CRBN Degrader-1 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group. PROTAC CRBN Degrader-1 is an cereblon (CRBN) degrader[1].

IC50 & Target

VHL

 

Cereblon

 

Molecular Weight

1061.25

Formula

C₅₃H₇₂N₈O₁₃S

CAS No.

2358775-70-7

SMILES

O=C(NC1=O)CCC1N(C2=O)C(C3=C2C(NCCNC(COCCCCCOCCOCCCCCOCC(N[[email protected]@H](C(C)(C)C)C(N4C[[email protected]](O)C[[email protected]]4C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)=O)=O)=CC=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (94.23 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9423 mL 4.7114 mL 9.4229 mL
5 mM 0.1885 mL 0.9423 mL 1.8846 mL
10 mM 0.0942 mL 0.4711 mL 0.9423 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (4.71 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 5 mg/mL (4.71 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (4.71 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.34%

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Keywords:

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Product Name:
PROTAC CRBN Degrader-1
Cat. No.:
HY-128845
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