2. PROTAC
  3. PROTAC Linkers
  4. Bis-PEG1-C-PEG1-CH2COOH

Bis-PEG1-C-PEG1-CH2COOH  (Synonyms: PROTAC Linker 26)

Cat. No.: HY-128847
Handling Instructions

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Bis-PEG1-C-PEG1-CH2COOH (PROTAC Linker 26) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Bis-PEG1-C-PEG1-CH2COOH Chemical Structure

Bis-PEG1-C-PEG1-CH2COOH Chemical Structure

CAS No. : 2358775-67-2

Size Price Stock Quantity
5 mg USD 60 In-stock
10 mg USD 90 In-stock
25 mg USD 180 In-stock
50 mg USD 280 In-stock
100 mg USD 450 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Bis-PEG1-C-PEG1-CH2COOH Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Bis-PEG1-C-PEG1-CH2COOH (PROTAC Linker 26) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bis-PEG1-C-PEG1-CH2COOH Related Antibodies
Molecular Weight

350.40

Formula

C16H30O8
CAS No.
Appearance

Oil

Color

Off-white to yellow

SMILES

OC(COCCCCCOCCOCCCCCOCC(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (285.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8539 mL 14.2694 mL 28.5388 mL
5 mM 0.5708 mL 2.8539 mL 5.7078 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8539 mL 14.2694 mL 28.5388 mL 71.3470 mL
5 mM 0.5708 mL 2.8539 mL 5.7078 mL 14.2694 mL
10 mM 0.2854 mL 1.4269 mL 2.8539 mL 7.1347 mL
15 mM 0.1903 mL 0.9513 mL 1.9026 mL 4.7565 mL
20 mM 0.1427 mL 0.7135 mL 1.4269 mL 3.5674 mL
25 mM 0.1142 mL 0.5708 mL 1.1416 mL 2.8539 mL
30 mM 0.0951 mL 0.4756 mL 0.9513 mL 2.3782 mL
40 mM 0.0713 mL 0.3567 mL 0.7135 mL 1.7837 mL
50 mM 0.0571 mL 0.2854 mL 0.5708 mL 1.4269 mL
60 mM 0.0476 mL 0.2378 mL 0.4756 mL 1.1891 mL
80 mM 0.0357 mL 0.1784 mL 0.3567 mL 0.8918 mL
100 mM 0.0285 mL 0.1427 mL 0.2854 mL 0.7135 mL
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Bis-PEG1-C-PEG1-CH2COOH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bis-PEG1-C-PEG1-CH2COOH2358775-67-2PROTAC Linker 26PROTAC Linker26PROTAC Linker-26PROTAC LinkersInhibitorinhibitorinhibit

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