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    Estrogen Receptor/ERR
  3. ERD-308

ERD-308 

Cat. No.: HY-128600
Handling Instructions

ERD-308 is a highly potent PROTAC degrader of estrogen receptor (ER) for ER positive breast cancer treatment. ERD-308 induces >95% of ER degradation at concentrations as low as 5 nM in both cell lines (DC50 (concentration causing 50% of protein degradation) of 0.17 nM and 0.43 nM in MCF-7 and T47D ER+ cells, respectively).

For research use only. We do not sell to patients.

ERD-308 Chemical Structure

ERD-308 Chemical Structure

CAS No. : 2320561-35-9

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Description

ERD-308 is a highly potent PROTAC degrader of estrogen receptor (ER) for ER positive breast cancer treatment. ERD-308 induces >95% of ER degradation at concentrations as low as 5 nM in both cell lines (DC50 (concentration causing 50% of protein degradation) of 0.17 nM and 0.43 nM in MCF-7 and T47D ER+ cells, respectively)[1].

IC50 & Target

DC50: 0.17 nM (ER in MCF-7 cells), 0.43 nM (ER in T47D ER+ cells)[1].

Molecular Weight

1004.26

Formula

C₅₅H₆₅N₅O₉S₂

CAS No.

2320561-35-9

SMILES

O=C(C1=C(C2=CC=C(O)C=C2)SC3=CC(O)=CC=C13)C4=CC=C(OCCN(CCCCCOCC(N[[email protected]@H](C(C)(C)C)C(N5[[email protected]](C(N[[email protected]@H](C)C6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[[email protected]@H](O)C5)=O)=O)CC)C=C4

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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ERD-308
Cat. No.:
HY-128600
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