2320561-35-9
Chemical Structure
ERD-308
- CAS No.: 2320561-35-9
- Formula:C55H65N5O9S2
- Molecular Weight:1004.26
IUPAC Name: (2S,4R)-1-((S)-2-(2-((5-(ethyl(2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)phenoxy)ethyl)amino)pentyl)oxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
InChIKey: BQXUPNKLZNSUMC-YUQWMIPFSA-N
SMILES: O=C(C1=C(C2=CC=C(O)C=C2)SC3=CC(O)=CC=C13)C4=CC=C(OCCN(CCCCCOCC(N[C@@H](C(C)(C)C)C(N5[C@H](C(N[C@@H](C)C6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5)=O)=O)CC)C=C4
Biological Activity: ERD-308 is a potent estrogen receptor (ER) PROTAC degrader. ERD-308 has DC50 values of 0.17 nM and 0.43 nM in MCF-7 and T47D ER+ cells. ERD-308 can inhibit the proliferation of breast cancer cells and exhibits anti-tumor activity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
ERD-308 | 98.13% | ERD-308 is a potent estrogen receptor (ER) PROTAC degrader. ERD-308 has DC50 values of 0.17 nM and 0.43 nM in MCF-7 and T47D ER+ cells. ERD-308 can inhibit the proliferation of breast cancer cells and exhibits anti-tumor activity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.62
HY-173135PROTAC KDM4 degrader-1 -
Similarity Score 0.61
HY-136001PROTAC α-synuclein degrader 3 -
Similarity Score 0.60
HY-130492ARCC-4 -
Similarity Score 0.60
HY-158429PROTAC CYP1B1 degrader-2 -
Similarity Score 0.60
HY-157765PROTAC ERα Degrader-6 -
Similarity Score 0.60
HY-152154PROTAC NAMPT Degrader-30 -
Similarity Score 0.60
HY-145762YM281 -
Similarity Score 0.59
HY-135309PROTAC ER Degrader-4 -
Similarity Score 0.59
HY-168016PROTAC YAP degrader-1 -
Explore the MedChemAI to find more analogs
