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PROTAC ER Degrader-4 

Cat. No.: HY-135309
Handling Instructions

PROTAC ER Degrader-4 is a PROATC estrogen receptor (ER) degrader, binding to ER with an IC50 of 0.8 nM. PROTAC ER Degrader-4 induces ER degradation in MCF-7 cells with an IC50 of 0.3 nM.

For research use only. We do not sell to patients.

PROTAC ER Degrader-4 Chemical Structure

PROTAC ER Degrader-4 Chemical Structure

CAS No. : 2361114-15-8

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Description

PROTAC ER Degrader-4 is a PROATC estrogen receptor (ER) degrader, binding to ER with an IC50 of 0.8 nM. PROTAC ER Degrader-4 induces ER degradation in MCF-7 cells with an IC50 of 0.3 nM[1].

IC50 & Target[1]

VHL

 

ER

 

In Vitro

PROTAC ER Degrader-4 shows equal to 100% ER degradation at 0.3 μM in the MCF-7 ER degradation cellular assay[1].

Molecular Weight

1005.19

Formula

C₅₃H₆₇F₃N₆O₈S

CAS No.

2361114-15-8

SMILES

CC(C)(F)CN1[[email protected]](C2=C(C=C(OCCOCCOCCOCC(N[[email protected]@H](C(C)(C)C)C(N3[[email protected]@H](C[[email protected]@H](O)C3)C(N[[email protected]](C4=CC=C(C5=C(N=CS5)C)C=C4)C)=O)=O)=O)C=C2F)F)C6=C(C7=CC=CC=C7N6)C[[email protected]]1C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PROTAC ER Degrader-4PROTAC ER Degrader4PROTAC ER Degrader 4PROTACEstrogen Receptor/ERRProteolysis-targeting chimeraERMCF-7BreastInhibitorinhibitorinhibit

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PROTAC ER Degrader-4
Cat. No.:
HY-135309
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