PROTAC AR-V7 degrader-1
Based on 2 publication(s) in Google Scholar
PROTAC AR-V7 degrader-1 is a selective AR-V7 degrader with a DC50 of 0.32 μM. PROTAC AR-V7 degrader-1 inhibits cancer cell proliferation. PROTAC AR-V7 degrader-1 is applicable to the research of castration-resistant prostate cancer.
(Pink: AR-V7 ligand (HY-117669); Blue: VHL ligand (HY-112078); Black: linker (HY-W041652)).
For research use only. We do not sell to patients.
- Purity: 98.19%
- CAS No.: 2767440-24-2
- Formula: C41H52N6O6S2
- Molecular Weight:789.02
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Anti-Cancer Compound Library
HY-L025
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Orally Active Compound Library
HY-L061
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Transcription Factor-Targeted Library
HY-L090
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Anti-Prostate Cancer Compound Library
HY-L124
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Nuclear Receptor Compound Library
HY-L126
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PROTAC Library
HY-L151
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Anti-Drug-Resistant Compound Library
HY-L169
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Multi-Target Compound Library
HY-L176
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MCE Bioactive Compound Library
HY-L001V
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High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) PROTAC AR-V7 degrader-1
MoreAll PROTACs Isoforms
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Biological Activity
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AR-V7 0.32 nM (DC50) |
VHL |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CWR22R | EC50 |
0.88 μM
Compound: 6
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Antiproliferative activity against human 22Rv1 cells expressing AR-V1
Antiproliferative activity against human 22Rv1 cells expressing AR-V1
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[PMID: 34767914] |
PROTAC AR-V7 degrader-1 (Compound 6) (0.01-10 μM) potently and selectively degrades AR-V7 in 22Rv1 cells via a proteasome- and VHL-dependent mechanism, with a DC50 of 0.32 μM and 67% maximum degradation[1].
PROTAC AR-V7 degrader-1 inhibits proliferation of 22Rv1 cells with an EC50 of 0.88 μM and 94% maximum efficacy[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2767440-24-2
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Appearance Solid
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Molecular Weight 789.02
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Formula C41H52N6O6S2
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Color White to off-white
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SMILES
O=C(CCCCOC1=CC=C(C2=CSC(N3CCOCC3)=N2)C=C1)N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@H](C4)O)C(N[C@H](C5=CC=C(C=C5)C6=C(N=CS6)C)C)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Single-cell imaging analysis, therapeutic modeling and a Phase Ib trial validate BCL-2 as a target across heterogeneous castration-resistant prostate cancer. [Abstract]2026 May 1;11(1):161. PMID: 42067541 -
Sci Adv
Lactate derived from cancer-associated fibroblasts promotes alternative splicing and castration resistance in prostate cancer. [Abstract]2026 Jan 16;12(3):eady5324. PMID: 41544173
Solvent & Solubility
DMSO : 110 mg/mL (139.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2674 mL | 6.3370 mL | 12.6739 mL | 31.6849 mL |
| 5 mM | 0.2535 mL | 1.2674 mL | 2.5348 mL | 6.3370 mL | |
| 10 mM | 0.1267 mL | 0.6337 mL | 1.2674 mL | 3.1685 mL | |
| 15 mM | 0.0845 mL | 0.4225 mL | 0.8449 mL | 2.1123 mL | |
| 20 mM | 0.0634 mL | 0.3168 mL | 0.6337 mL | 1.5842 mL | |
| 25 mM | 0.0507 mL | 0.2535 mL | 0.5070 mL | 1.2674 mL | |
| 30 mM | 0.0422 mL | 0.2112 mL | 0.4225 mL | 1.0562 mL | |
| 40 mM | 0.0317 mL | 0.1584 mL | 0.3168 mL | 0.7921 mL | |
| 50 mM | 0.0253 mL | 0.1267 mL | 0.2535 mL | 0.6337 mL | |
| 60 mM | 0.0211 mL | 0.1056 mL | 0.2112 mL | 0.5281 mL | |
| 80 mM | 0.0158 mL | 0.0792 mL | 0.1584 mL | 0.3961 mL | |
| 100 mM | 0.0127 mL | 0.0634 mL | 0.1267 mL | 0.3168 mL |
PROTAC AR-V7 degrader-1 Related Classifications
HY-145479 Related Classifications
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