1. PROTAC
    Apoptosis
  2. PROTAC
    RIP kinase
  3. PROTAC RIPK degrader-2

PROTAC RIPK degrader-2 

Cat. No.: HY-111866 Purity: 99.05%
Handling Instructions

PROTAC RIPK degrader-2 is a nonpeptidic PROTAC which potently targets serine-threonine kinase RIPK2 and has highly selective for RIPK2 degradation.

For research use only. We do not sell to patients.

PROTAC RIPK degrader-2 Chemical Structure

PROTAC RIPK degrader-2 Chemical Structure

CAS No. : 1801547-16-9

Size Price Stock Quantity
5 mg USD 850 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1250 In-stock
Estimated Time of Arrival: December 31
25 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

PROTAC RIPK degrader-2 is a nonpeptidic PROTAC which potently targets serine-threonine kinase RIPK2 and has highly selective for RIPK2 degradation[1].

IC50 & Target[1]

VHL

 

Molecular Weight

1060.31

Formula

C₅₂H₆₅N₇O₁₁S₃

CAS No.

1801547-16-9

SMILES

CC1=C(SC=N1)C2=CC=C(CNC([[email protected]]3N(C([[email protected]](C(C)(C)C)NC(COCCOCCOCCOCCOC4=CC5=C(C(NC6=CC=C(SC=N7)C7=C6)=CC=N5)C=C4S(C(C)(C)C)(=O)=O)=O)=O)C[[email protected]](O)C3)=O)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (141.47 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9431 mL 4.7156 mL 9.4312 mL
5 mM 0.1886 mL 0.9431 mL 1.8862 mL
10 mM 0.0943 mL 0.4716 mL 0.9431 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 7.5 mg/mL (7.07 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 7.5 mg/mL (7.07 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PROTAC RIPK degrader-2PROTAC RIPK degrader2PROTAC RIPK degrader 2PROTACRIP kinaseProteolysis-targeting chimeraReceptor-interacting protein kinasesRIPKInhibitorinhibitorinhibit

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Product Name:
PROTAC RIPK degrader-2
Cat. No.:
HY-111866
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