1. PROTAC
    GPCR/G Protein
  2. PROTAC
    Ras
  3. PROTAC KRASG12C Degrader-LC-2

PROTAC KRASG12C Degrader-LC-2 

Cat. No.: HY-137516
Handling Instructions

PROTAC KRASG12C Degrader-LC-2 is a potent and first-in-class degrader of endogenous KRAS G12C with DC50 values between 0.25 and 0.76 μM. PROTAC KRASG12C Degrader-LC-2 is composed of a covalent KRAS G12C inhibitor MRTX849, a VHL ligand and a linker.

For research use only. We do not sell to patients.

PROTAC KRASG12C Degrader-LC-2 Chemical Structure

PROTAC KRASG12C Degrader-LC-2 Chemical Structure

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products

View All PROTAC Isoform Specific Products:

View All Ras Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PROTAC KRASG12C Degrader-LC-2 is a potent and first-in-class degrader of endogenous KRAS G12C with DC50 values between 0.25 and 0.76 μM. PROTAC KRASG12C Degrader-LC-2 is composed of a covalent KRAS G12C inhibitor MRTX849, a VHL ligand and a linker[1].

IC50 & Target[1]

KRAS(G12C)

0.25-0.76 μM (DC50)

VHL

 

In Vitro

PROTAC KRASG12C Degrader-LC-2 (LC-2) (0.25-10 μM) impairs ERK phosphorylation in NCI-H2030 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1132.78

Formula

C₅₉H₇₁ClFN₁₁O₇S

SMILES

O=C([[email protected]]1N(C([[email protected]@H](NC(CCOCCCN2[[email protected]](COC3=NC(N4C[[email protected]](CC#N)N(C(C(F)=C)=O)CC4)=C5C(CN(C6=C7C(Cl)=CC=CC7=CC=C6)CC5)=N3)CCC2)=O)C(C)(C)C)=O)C[[email protected]](O)C1)NCC8=CC=C(C9=C(C)N=CS9)C=C8

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PROTAC KRASG12C Degrader-LC-2PROTACRasProteolysis-targeting chimeraundruggabledegraderphosphorylationNCI-H2030cellsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
PROTAC KRASG12C Degrader-LC-2
Cat. No.:
HY-137516
Quantity:
MCE Japan Authorized Agent: