2. Signaling Pathways
  3. PROTAC
  4. PROTACs
  5. von Hippel-Lindau (VHL) Isoform
  6. von Hippel-Lindau (VHL) Degrader

von Hippel-Lindau (VHL) Degrader

von Hippel-Lindau (VHL) Degraders (3):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-115718
    PZ703b 2471970-56-4 98.47%
    PZ703b is a Bcl-xl PROTAC degrader that induces apoptosis and inhibits cancer cell proliferation. PZ703b can be used for the research of bladder cancer research.
    PZ703b
  • HY-158048
    UNC9036
    UNC9036 is a PROTAC-based STING degrader, with a DC50 of 227 nM. UNC9036-mediated STING degradation is proteasome and VHL dependent (Srtucture Note: Red, STING agonist diABZI (HY-112921A); Blue, VHL ligand VH032 (HY-120217); Black, linker).
    UNC9036
  • HY-152154
    Nampt degrader-2
    Nampt degrader-2 is a fluorescent PROTAC, which efficiently degrades NAMPT with an IC50 of 41.9 nM. Nampt degrader-2 binds to NAMPT and VHL to form a ternary complex and subsequently induced NAMPT degradation via ubiquitin-proteasome system (UPS). Nampt degrader-2 leads to significant reduction of NAD+ and exerts potent antitumor activities.
    Nampt degrader-2