1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK14 Isoform


CDK14, also named PFTAIREI, is a CDC2-associated serine/threonine protein kinase and can act as an essential regulator of CCNs and cell cycle development. Interestingly, CDK14 can regulate cell cycle progression and cell proliferation by interacting with CCNY that is the regulatory submit of CDK14 and promotes Wnt signaling by mediating cell cycle-dependent low-density-lipoprotein receptor-related protein 6 (LRP6) phosphorylation which is a key regulatory nexus in Wnt/β-catenin pathway.

CDK14 Related Products (2):

Cat. No. Product Name Effect Purity
  • HY-127104
    Inhibitor 98.92%
    FMF-04-159-2 is a covalent CDK14 inhibitor. FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6 nM and 256 nM in NanoBRET assay, respectively.
  • HY-X0150
    Inhibitor 98.36%
    JSH-150 is a highly selective and potent CDK9 inhibitor with an IC50 of 1 nM.