1. Cell Cycle/DNA Damage
  2. CDK
  3. FMF-04-159-2

FMF-04-159-2 

Cat. No.: HY-127104 Purity: 99.34%
Handling Instructions

FMF-04-159-2 is a covalent CDK14 inhibitor. FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6 nM and 256 nM in NanoBRET assay, respectively.

For research use only. We do not sell to patients.

FMF-04-159-2 Chemical Structure

FMF-04-159-2 Chemical Structure

CAS No. : 2364489-81-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 526 In-stock
Estimated Time of Arrival: December 31
1 mg USD 120 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
25 mg USD 990 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

FMF-04-159-2 is a covalent CDK14 inhibitor. FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6 nM and 256 nM in NanoBRET assay, respectively[1].

IC50 & Target[1]

CDK14/Cyclin Y

39.6 nM (IC50, in NanoBRET assay)

CDK2

256 nM (IC50, in NanoBRET assay)

In Vitro

FMF-04-159-2 inhibits HCT116 proliferation with an IC50 of 1,144±190 nM[1].

Molecular Weight

683.01

Formula

C₂₈H₃₀Cl₃N₇O₅S

CAS No.

2364489-81-4

SMILES

O=C(C1=NNC=C1NC(C2=C(Cl)C=C(Cl)C=C2Cl)=O)NC3CCN(S(=O)(C4=CC=CC(NC(/C=C/CN(C)C)=O)=C4)=O)CC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (366.03 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4641 mL 7.3205 mL 14.6411 mL
5 mM 0.2928 mL 1.4641 mL 2.9282 mL
10 mM 0.1464 mL 0.7321 mL 1.4641 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.05 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.05 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
FMF-04-159-2
Cat. No.:
HY-127104
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