1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK12 Isoform


Cyclin-dependent kinase 12 (CDK12) belongs to the cyclin-dependent kinase (CDK) family of serine/threonine protein kinases that regulate transcriptional and post-transcriptional processes, thereby modulating multiple cellular functions. Early studies characterised CDK12 as a transcriptional CDK that complexes with cyclin K to mediate gene transcription by phosphorylating RNA polymerase II. CDK12 has been demonstrated to specifically upregulate the expression of genes involved in response to DNA damage, stress and heat shock. More recent studies have implicated CDK12 in regulating mRNA splicing, 3' end processing, pre-replication complex assembly and genomic stability during embryonic development. Genomic alterations in CDK12 have been detected in oesophageal, stomach, breast, endometrial, uterine, ovarian, bladder, colorectal and pancreatic cancers, ranging from 5% to 15% of sequenced cases. An increasing number of studies point to CDK12 inhibition as an effective strategy to inhibit tumour growth, and synthetic lethal interactions have been described with MYC, EWS/FLI and PARP/CHK1 inhibition.  CDK12 and the highly homologous protein CDK13 are both activated upon binding to cyclin K to regulate transcription through phosphorylating Ser2 residues located on the C-terminal domain (CTD) of RNA-polymerase II (RNA-Pol2) which contains 52 repeats of the YSPTSPS motif.

CDK12 Related Products (17):

Cat. No. Product Name Effect Purity