1. Cell Cycle/DNA Damage
  2. CDK
  3. CMPD 7

CMPD 7 

Cat. No.: HY-112261
Handling Instructions

CMPD 7 is a potent and selective CDK12 inhibitor with an IC50 of 491 nM in enzymatic assay.

For research use only. We do not sell to patients.

CMPD 7 Chemical Structure

CMPD 7 Chemical Structure

CAS No. : 2220184-50-7

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Description

CMPD 7 is a potent and selective CDK12 inhibitor with an IC50 of 491 nM in enzymatic assay.

IC50 & Target

IC50: 491 nM (CDK12)[1]

In Vitro

CMPD 7 is a highly selective CDK12 inhibitor profiled across a panel of 352 kinases at 0.1 µM. CMPD 7 shows potent inhibition of phosphorylation of Ser2 on the CTD repeat domain of RNA Pol II as well as growth inhibition of OV90 cells and acute cytotoxicity to THP1 cells[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

470.52

Formula

C₂₃H₂₈F₂N₈O

CAS No.

2220184-50-7

SMILES

CC(C)N1C2=NC(N3CCCC[[email protected]]3CCO)=NC(NCC4=NC5=C(C(F)=C(F)C=C5)N4)=C2N=C1

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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C1   V1   C2   V2

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Product Name:
CMPD 7
Cat. No.:
HY-112261
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CMPD 7

Cat. No.: HY-112261