1. Cell Cycle/DNA Damage
  2. CDK
  3. CDK12-IN-3

CDK12-IN-3 

Cat. No.: HY-112261 Purity: 98.22%
Handling Instructions

CDK12-IN-3 is a potent and selective CDK12 inhibitor with an IC50 of 491 nM in enzymatic assay.

For research use only. We do not sell to patients.

CDK12-IN-3 Chemical Structure

CDK12-IN-3 Chemical Structure

CAS No. : 2220184-50-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 466 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2550 In-stock
Estimated Time of Arrival: December 31
100 mg USD 4350 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

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Description

CDK12-IN-3 is a potent and selective CDK12 inhibitor with an IC50 of 491 nM in enzymatic assay.

IC50 & Target[1]

CDK12

491 nM (IC50)

In Vitro

CDK12-IN-3 is a highly selective CDK12 inhibitor profiled across a panel of 352 kinases at 0.1 µM. CDK12-IN-3 shows potent inhibition of phosphorylation of Ser2 on the CTD repeat domain of RNA Pol II as well as growth inhibition of OV90 cells and acute cytotoxicity to THP1 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

470.52

Formula

C₂₃H₂₈F₂N₈O

CAS No.

2220184-50-7

SMILES

CC(C)N1C2=NC(N3CCCC[[email protected]]3CCO)=NC(NCC4=NC5=C(C(F)=C(F)C=C5)N4)=C2N=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (531.33 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1253 mL 10.6265 mL 21.2531 mL
5 mM 0.4251 mL 2.1253 mL 4.2506 mL
10 mM 0.2125 mL 1.0627 mL 2.1253 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.33 mg/mL (4.95 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.33 mg/mL (4.95 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

CDK12-IN-3CDKCyclin dependent kinaseInhibitorinhibitorinhibit

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Product Name:
CDK12-IN-3
Cat. No.:
HY-112261
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