1. Cell Cycle/DNA Damage
    Apoptosis
  2. CDK
    Apoptosis
  3. SR-4835

SR-4835 

Cat. No.: HY-130250
Handling Instructions

SR-4835 is a potent, highly selective and ATP competitive dual inhibitor of CDK12/CDK13 (CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM). SR-4835 acts in synergy with DNA-damaging chemotherapy and PARP inhibitors and provokes triple-negative breast cancer (TNBC) cell death.

For research use only. We do not sell to patients.

SR-4835 Chemical Structure

SR-4835 Chemical Structure

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Description

SR-4835 is a potent, highly selective and ATP competitive dual inhibitor of CDK12/CDK13 (CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM). SR-4835 acts in synergy with DNA-damaging chemotherapy and PARP inhibitors and provokes triple-negative breast cancer (TNBC) cell death[1].

IC50 & Target[1]

CDK12

99 nM (IC50)

CDK12

98 nM (Kd)

CDK13

4.9 nM (Kd)

In Vitro

SR-4835 (90 nM; 0.5-48 hours) suppresses ATM and RAD51 protein levels[1].
SR-4835 inhibits CDK12/CDK13 which triggers intronic polyadenylation site cleavage and suppresses the expression of core DNA damage response proteins[1].

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 90 nM
Incubation Time: 0.5, 6, 24, 48 hours
Result: Suppressed ATM and RAD51 protein levels.
Molecular Weight

499.36

Formula

C₂₁H₂₀Cl₂N₁₀O

SMILES

CN1N=CC(N2C3=NC(N4CCOCC4)=NC(NCC5=NC6=C(N5)C=C(Cl)C(Cl)=C6)=C3N=C2)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

SR-4835SR4835SR 4835CDKApoptosisCyclin dependent kinaseInhibitorinhibitorinhibit

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SR-4835
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