1. Cell Cycle/DNA Damage
    Apoptosis
  2. CDK
    Apoptosis
  3. SR-4835

SR-4835 

Cat. No.: HY-130250 Purity: 98.46%
Handling Instructions

SR-4835 is a potent, highly selective and ATP competitive dual inhibitor of CDK12/CDK13 (CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM). SR-4835 acts in synergy with DNA-damaging chemotherapy and PARP inhibitors and provokes triple-negative breast cancer (TNBC) cell death.

For research use only. We do not sell to patients.

SR-4835 Chemical Structure

SR-4835 Chemical Structure

CAS No. : 2387704-62-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 428 In-stock
Estimated Time of Arrival: December 31
5 mg USD 390 In-stock
Estimated Time of Arrival: December 31
10 mg USD 650 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

SR-4835 is a potent, highly selective and ATP competitive dual inhibitor of CDK12/CDK13 (CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM). SR-4835 acts in synergy with DNA-damaging chemotherapy and PARP inhibitors and provokes triple-negative breast cancer (TNBC) cell death[1].

IC50 & Target[1]

CDK12

99 nM (IC50)

CDK12

98 nM (Kd)

CDK13

4.9 nM (Kd)

In Vitro

SR-4835 (90 nM; 0.5-48 hours) suppresses ATM and RAD51 protein levels[1].
SR-4835 inhibits CDK12/CDK13 which triggers intronic polyadenylation site cleavage and suppresses the expression of core DNA damage response proteins[1].

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 90 nM
Incubation Time: 0.5, 6, 24, 48 hours
Result: Suppressed ATM and RAD51 protein levels.
Molecular Weight

499.36

Formula

C₂₁H₂₀Cl₂N₁₀O

CAS No.

2387704-62-1

SMILES

CN1N=CC(N2C3=NC(N4CCOCC4)=NC(NCC5=NC6=C(N5)C=C(Cl)C(Cl)=C6)=C3N=C2)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (10.01 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0026 mL 10.0128 mL 20.0256 mL
5 mM 0.4005 mL 2.0026 mL 4.0051 mL
10 mM 0.2003 mL 1.0013 mL 2.0026 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 98.46%

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Keywords:

SR-4835SR4835SR 4835CDKApoptosisCyclin dependent kinaseInhibitorinhibitorinhibit

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SR-4835
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