2387704-62-1
2387704-62-1
Chemical Structure
SR-4835
- CAS No.: 2387704-62-1
- Formula:C21H20Cl2N10O
- Molecular Weight:499.36
IUPAC Name: N-((5,6-dichloro-1H-benzo[d]imidazol-2-yl)methyl)-9-(1-methyl-1H-pyrazol-4-yl)-2-morpholino-9H-purin-6-amine
InChIKey: FSELUFUYNUNZKD-UHFFFAOYSA-N
SMILES: CN1N=CC(N2C3=NC(N4CCOCC4)=NC(NCC5=NC6=C(N5)C=C(Cl)C(Cl)=C6)=C3N=C2)=C1
Biological Activity: SR-4835 is a potent, highly selective and ATP competitive dual inhibitor of CDK12/CDK13 (CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM). SR-4835 acts in synergy with DNA-damaging chemotherapy and PARP inhibitors and provokes triple-negative breast cancer (TNBC) cell death[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SR-4835 | 99.47% | SR-4835 is a potent, highly selective and ATP competitive dual inhibitor of CDK12/CDK13 (CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM). SR-4835 acts in synergy with DNA-damaging chemotherapy and PARP inhibitors and provokes triple-negative breast cancer (TNBC) cell death. | ||||||||||||||||||||
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