FKBP12 PROTAC RC32  (Synonyms: RC32)

FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTAC technology. FKBP12 PROTAC RC32 contains conjugation of Rapamycin (HY-10219) and a ligand for an Cereblon E3 ubiquitin ligase (Pomalidomide; HY-10984)^[1].

FKBP12 PROTAC RC32 (RC32; 0.1-1000 nM; for 12 hours) results in 50% protein degradation (DC₅₀) of ~0.3 nM after only 12 hours of treatment^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RC32 (RC32; i.p.; 30 mg/kg; twice a day; 1 day) degrades the FKBP12 protein in most of the organs of treated mice, except for the brain after only 1 day of treatment in mice^[1].
RC32 (orally; 60 mg/kg; twice a day; for 1 day) significantly degrades FKBP12 in mice^[1].
RC32 (i.p.; 8 mg/kg; twice a day; for 2 days) efficiently degrades the FKBP12 protein in most of the organs examined in Bama pigs (20 kg) ^[1].
RC32 (i.p.; 8 mg/kg; twice a day; for 3 days) efficiently degrades FKBP12 in the heart, liver, kidney, spleen, lung, and stomach of rhesus monkeys^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1426.69

Solid

C₇₅H₁₀₇N₇O₂₀

2375555-66-9

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• [1]. A chemical approach for global protein knockdown from mice to non-human primates. Cell Discov. 2019 Feb 5;5:10.  [Content Brief]