FKBP12

FKBP12 Related Products (35):

By Type:	Pan (1)
By Effects:	Inhibitors (6) Modulators (2) Degraders (13) Ligands (4)

Cat. No.	Product Name	Effect	Purity

HY-10219

Rapamycin		99.94%
Rapamycin (Sirolimus; AY 22989) is a potent and specific blood-brain barrier-transmissible mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant.

HY-114421

FKBP12 PROTAC dTAG-13	Degrader	99.89%
FKBP12 PROTAC dTAG-13 (dTAG-13), a PROTAC-based heterobifunctional degrader, is a selective degrader of FKBP12^F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 effectively engages FKBP12^F36V and CRBN, thereby selectively degrading FKBP12^F36V.

HY-112210

Shield-1	Modulator	99.73%
Shield-1 (Shld1) is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize proteins tagged with a mutated FKBP12-derived destabilization domain (DD).

HY-145514

dTAGV-1 TFA	Degrader	99.97%
dTAGV-1 TFA is a potent and selective degrader of FKBP12^F36V-tagged proteins PROTAC degrader. dTAGV-1 TFA can induce degradation of FKBP12^F36V-Nluc in vivo. (Pink: Target Protein Ligand (HY-114420); Black: Linker (HY-W012001); Blue: VHL Ligand (HY-112078); VHL Ligan+Linker (HY-173628A))

HY-145514C

dTAGV-1 hydrochloride	Degrader	99.94%
dTAGV-1 hydrochloride is a potent and selective degrader of FKBP12^F36V-tagged proteins PROTAC degrader. dTAGV-1 hydrochloride can induce degradation of FKBP12^F36V-Nluc in vivo. (Pink: Target Protein Ligand (HY-114420); Black: Linker (HY-W012001); Blue: VHL Ligand (HY-112078); VHL Ligan+Linker (HY-173628A)).

HY-169679

WAY-380153	Inhibitor
WAY-380153 (Compound 24) is an FKBP12 inhibitor. WAY-380153 exhibits moderate binding affinity for FKBP12, with a KD of 19 μM (measured by ITC) and 15 μM (measured by NMR). WAY-380153 can be used in research related to neurotrophy and neuroprotection.

HY-147098

dTAG-47	Degrader	99.65%
dTAG-47 is a FKBP12F36V PROTAC degrader. dTAG-47 efficiently degrades FKBP12F36V-MELK(sg3R) in MELK^⁻/⁻ MDA-MB-468-FKBP12F36V-MELK(sg3R) cells. dTAG-47 can be used for the research of basal-like breast cancers (BBC). (Pink: FKBP12F36V ligand (HY-114420), Blue: CRBN Ligand (HY-W087383), Black: Linker (HY-42773), E3 ligase ligand-linker conjugate (HY-175952)).

HY-145514A

dTAGV-1-NEG		99.73%
dTAGV-1-NEG is a diastereomer and as a heterobifunctional negative control of dTAGV-1. dTAGV-1 is an FKBP12^F36V-selective degrader.

HY-123941

FKBP12 PROTAC dTAG-7	Inhibitor	99.47%
FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional PROTAC degrader. FKBP12 PROTAC dTAG-7 targets FKBP12^F36V and BET BRD4. FKBP12 PROTAC dTAG-7 enables rapid and selective degradation of target proteins, and is suitable for cellular and in vivo studies to analyze protein functions and validate targets. (Pink: target protein ligand (HY-114420); Black: linker (HY-128844); Blue: CRBN Ligand (HY-103597); CRBN Ligand+linker: (HY-W722323))

HY-153806

RapaBlock	Modulator	98.0%
RapaBlock is a potent, non-immunosuppressive and brain-impermeable FKBP12 ligand.

HY-114434

AP1867		99.48%
AP1867 is a synthetic FKBP12^F36V-directed ligand.

HY-145514D

dTAGV-1	Degrader	98.43%
dTAGV-1 is a potent and selective degrader of FKBP12^F36V-tagged proteins PROTAC degrader. dTAGV-1 can induce degradation of FKBP12^F36V-Nluc in vivo. (Pink: Target Protein Ligand (HY-114420); Black: Linker (HY-W012001); Blue: VHL Ligand (HY-112078); VHL Ligan+Linker (HY-173628A)).

HY-114420

AP1867-2-(carboxymethoxy)	Inhibitor	99.88%
AP1867-2-(carboxymethoxy), the AP1867 (a synthetic FKBP12^F36V-directed ligand) based moiety, binds to CRBN ligand via a linker to form dTAG molecules.

HY-130835

FKBP12 PROTAC RC32
FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTAC technology. FKBP12 PROTAC RC32 contains conjugation of Rapamycin (HY-10219) and a ligand for an Cereblon E3 ubiquitin ligase (Pomalidomide; HY-10984).

HY-103634

dFKBP-1	Inhibitor	98.00%
dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF (HY-114872) of FKBP12, the Thalidomide based Cereblon ligand and a linker.

HY-129610

KB02-SLF	Inhibitor	99.25%
KB02-SLF is a PROTAC-based nuclear FKBP12 degrader (molecular glue). KB02-SLF promotes nuclear FKBP12 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. SLF binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-SLF.

HY-163807

22-SLF	Degrader
22-SLF is a PROTAC degrader, that degrades FK506-binding protein 12 (FKBP12) with a DC₅₀ of 0.5 µM. 22-SLF interacts with C227 and C228 in FBXO22 to induce a ternary complex between FKBP12 and FBXO22, and degrades FKBP12 in a FBXO22-dependent manner. 22-SLF can be used for fundamental cancer research as a probe to study the FBXO22 degradation pathway. (Pink: FKBP12 ligand (HY-114872); Black: Linker (HY-163821); Blue: FBXO22 ligand (HY-163826)).

HY-10219S

Rapamycin-d₃
Rapamycin-d₃ is the deuterium labeled Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC₅₀ of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant.

HY-161794A

SP3N hydrochloride	Degrader	99.84%
SP3N hydrochloride is a specific degrader of the prolyl isomerase (FKBP12). The alkylamine of SP3N hydrochloride is metabolized to a reactive aldehyde (SP3CHO), which recruits the SCF^FBXO22 ligase for FKBP12 degradation. SP3N hydrochloride may be used in research for cancer.

HY-129363

AP1867-3-(aminoethoxy)		98.60%
AP1867-3-(aminoethoxy), the AP1867 (HY-114434) based moiety, is a synthetic ligand for FKBP. AP1867-3-(aminoethoxy) can be used in the synthesis of PROTAC FKBP12 F36V degrader.

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