2. Apoptosis Immunology/Inflammation Cell Cycle/DNA Damage Autophagy PROTAC
  3. FKBP PROTACs
  4. dTAGV-1 hydrochloride

dTAGV-1 hydrochloride is a potent and selective degrader of FKBP12F36V-tagged proteins PROTAC degrader. dTAGV-1 hydrochloride can induce degradation of FKBP12F36V-Nluc in vivo. (Pink: Target Protein Ligand (HY-114420); Black: Linker (HY-W012001); Blue: VHL Ligand (HY-112078); VHL Ligan+Linker (HY-173628A)).

For research use only. We do not sell to patients.

CAS No. : 2624313-16-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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10 mM * 1 mL in DMSO In-stock
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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of dTAGV-1 hydrochloride:

dTAGV-1 hydrochloride Related Antibodies

Top Publications Citing Use of Products

    dTAGV-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Nature. 2025 Feb;638(8052):1095-1103.  [Abstract]

    dTAGV-1 hydrochloride (500 nM; 0-48 h) depleted FOCAD protein levels within four hours. Following FOCAD degradation, levels of SKIV2L, TTC37 and AVEN protein decreased by 8 h, reaching a maximum by 2 days in MIAPACA2 FOCAD-dTAG cells.

    dTAGV-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Sci Adv. 2025 Nov 28;11(48):eadz2345.  [Abstract]

    Western blot analysis of total RNAPII, degraded RPB1 (tagged with GFP), and RNAPIImut (tagged with HA; WT, Y1F, S2A, T4V, S5A and S7A) levels before and after Doxycycline (Dox) or dTAGV-1 TFA (100 nM) treatment. α-Tubulin served as the loading control.

    dTAGV-1 hydrochloride purchased from MedChemExpress. Usage Cited in: Mayo Clinic. 2025.

    Representative Western blot analysis of KLF5 after 250 nM dTAGV-1 TFA treatment for 0, 1, 4 and 24 h. HSC70 was used as a loading control.

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    von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    dTAGV-1 hydrochloride is a potent and selective degrader of FKBP12F36V-tagged proteins PROTAC degrader. dTAGV-1 hydrochloride can induce degradation of FKBP12F36V-Nluc in vivo. (Pink: Target Protein Ligand (HY-114420); Black: Linker (HY-W012001); Blue: VHL Ligand (HY-112078); VHL Ligan+Linker (HY-173628A))[1].

    IC50 & Target

    FKBP12

     

    In Vitro

    dTAGV-1 (0.1 nM-10 μM; 24 h) hydrochloride induces potent degradation of FKBP12F36V-Nluc with no effects on FKBP12WT-Nluc in 293FT cells[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    dTAGV-1 hydrochloride Related Antibodies
    In Vivo

    dTAGV-1 (35 mg/kg; i.p; 3 days) hydrochloride induces degradation of FKBP12F36V-Nluc in mice[1].
    Pharmacokinetic Analysis in Mice (non-salt form)[1]

    Route Dose (mg/kg) Tmax (hr) t1/2 (hr) Cmax (ng/mL) AUClast (hr·ng/mL) AUCinf (hr·ng/mL) CL (mL/min/kg) Vss (L/kg)
    i.v. 2 0.08 3.02 7780 3245 3329 10.1 0.56
    i.p. 10 2.00 4.43 2123 18088 18517 9.05 /
    i.p. 2 1.67 3.64 595 2245 3136 10.7 /

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    1284.00

    Formula

    C68H91ClN6O14S
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C([C@H]1N(CCCC1)C([C@H](C2=CC(OC)=C(C(OC)=C2)OC)CC)=O)O[C@@H](C3=C(C=CC=C3)OCC(NCCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@H](C4)O)C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)=O)=O)=O)CCC7=CC(OC)=C(C=C7)OC.Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (77.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.7788 mL 3.8941 mL 7.7882 mL
    5 mM 0.1558 mL 0.7788 mL 1.5576 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.94%

    SDS (251 KB)

    COA (252 KB) HNMR (159 KB) RP-HPLC (241 KB) MS (198 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 0.7788 mL 3.8941 mL 7.7882 mL 19.4704 mL
    5 mM 0.1558 mL 0.7788 mL 1.5576 mL 3.8941 mL
    10 mM 0.0779 mL 0.3894 mL 0.7788 mL 1.9470 mL
    15 mM 0.0519 mL 0.2596 mL 0.5192 mL 1.2980 mL
    20 mM 0.0389 mL 0.1947 mL 0.3894 mL 0.9735 mL
    25 mM 0.0312 mL 0.1558 mL 0.3115 mL 0.7788 mL
    30 mM 0.0260 mL 0.1298 mL 0.2596 mL 0.6490 mL
    40 mM 0.0195 mL 0.0974 mL 0.1947 mL 0.4868 mL
    50 mM 0.0156 mL 0.0779 mL 0.1558 mL 0.3894 mL
    60 mM 0.0130 mL 0.0649 mL 0.1298 mL 0.3245 mL
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    dTAGV-1 hydrochloride Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    dTAGV-12624313-16-0dTAGV1dTAGV 1FKBPPROTACsFK506-binding proteinhydrochlorideFKBP12degradercancerInhibitorinhibitorinhibit

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