dTAGV-1-NEG TFA
dTAGV-1-NEG TFA is a diastereomer and as a heterobifunctional negative control of dTAGV-1. dTAGV-1-NEG TFA is an FKBP12F36V-selective degrader.
(Pink: FKBP12 ligand (HY-114420); Blue: VHL ligand (HY-173627); Black: linker (HY-W012001)).
For research use only. We do not sell to patients.
- Formula: C70H91F3N6O16S
- Molecular Weight:1361.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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FKBP12 |
dTAGV-1-NEG TFA (1-10 μM; 24 h) not induces the degradation of FKBP12F36V-Nluc on 293FT FKBP12F36V-Nluc or FKBP12WT-Nluc cells[1].
dTAGV-1-NEG TFA (500 nM; 24 h) dose not induce the degradation of KRASG12V protein in PATU-8902 FKBP12F36V-KRASG12V and KRAS / cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PATU-8902 FKBP12F36V-KRASG12V, KRAS−/− cells
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Concentration:50, 500 nM
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Incubation Time:24 hours
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Result:Not induced the degradation of KRASG12V protein.
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Cell Line:EWS502 FKBP12F36V-GFP cells
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Concentration:1 μM
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Incubation Time:0, 2, 4, 6, 8 days
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Result:Showed relative growth of cells same as the control group, higher than dTAGV-1 treated group.
Chemical Information
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Molecular Weight 1361.56
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Formula C70H91F3N6O16S
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SMILES
O=C([C@H]1N(C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[C@@H](C3=CC=CC=C3OCC(NCCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)C[C@H](O)C4)=O)=O)=O)CCC7=CC=C(OC)C(OC)=C7.OC(C(F)(F)F)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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