SP3N hydrochloride
Based on 1 Customer Validation
SP3N hydrochloride is a specific degrader of the prolyl isomerase (FKBP12). The alkylamine of SP3N hydrochloride is metabolized to a reactive aldehyde (SP3CHO), which recruits the SCFFBXO22 ligase for FKBP12 degradation. SP3N hydrochloride may be used in research for cancer.
For research use only. We do not sell to patients.
- Purity: 99.84%
- Formula: C39H58ClN3O10
- Molecular Weight:764.34
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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FKBP12 |
Chemical Information
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Appearance Solid
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Molecular Weight 764.34
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Formula C39H58ClN3O10
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Color White to off-white
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SMILES
COC1=CC=C(CC[C@@H](OC([C@@H]2CCCCN2C(C(C(C)(C)CC)=O)=O)=O)C3=CC(NC(CCOCCOCCOCCN)=O)=CC=C3)C=C1OC.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (130.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3083 mL | 6.5416 mL | 13.0832 mL | 32.7080 mL |
| 5 mM | 0.2617 mL | 1.3083 mL | 2.6166 mL | 6.5416 mL | |
| 10 mM | 0.1308 mL | 0.6542 mL | 1.3083 mL | 3.2708 mL | |
| 15 mM | 0.0872 mL | 0.4361 mL | 0.8722 mL | 2.1805 mL | |
| 20 mM | 0.0654 mL | 0.3271 mL | 0.6542 mL | 1.6354 mL | |
| 25 mM | 0.0523 mL | 0.2617 mL | 0.5233 mL | 1.3083 mL | |
| 30 mM | 0.0436 mL | 0.2181 mL | 0.4361 mL | 1.0903 mL | |
| 40 mM | 0.0327 mL | 0.1635 mL | 0.3271 mL | 0.8177 mL | |
| 50 mM | 0.0262 mL | 0.1308 mL | 0.2617 mL | 0.6542 mL | |
| 60 mM | 0.0218 mL | 0.1090 mL | 0.2181 mL | 0.5451 mL | |
| 80 mM | 0.0164 mL | 0.0818 mL | 0.1635 mL | 0.4088 mL | |
| 100 mM | 0.0131 mL | 0.0654 mL | 0.1308 mL | 0.3271 mL |
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