2265886-81-3
Chemical Structure
dTAG-47
- CAS No.: 2265886-81-3
- Formula:C59H73N5O14
- Molecular Weight:1076.24
IUPAC Name: (1R)-3-(3,4-dimethoxyphenyl)-1-(2-(2-((8-((1,3-dioxo-2-(2-oxopiperidin-3-yl)isoindolin-5-yl)amino)octyl)amino)-2-oxoethoxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
InChIKey: OQXAQHQPOQLCAE-ODPQSFPTSA-N
SMILES: O=C1N(C2C(NC(CC2)=O)=O)C(C3=CC=C(NCCCCCCCCNC(COC4=C(C=CC=C4)[C@@H](CCC5=CC(OC)=C(C=C5)OC)OC([C@H]6N(CCCC6)C([C@H](C7=CC(OC)=C(C(OC)=C7)OC)CC)=O)=O)=O)C=C31)=O
Biological Activity: dTAG-47 is a heterobifunctional PROTAC degrader that specifically binds to the FKBP12F36V domain and Cereblon (CRBN). By recruiting the CRBN E3 ubiquitin ligase, dTAG-47 induces ubiquitination and proteasomal degradation of FKBP12F36V-fused Cas9 and tagged KDM5A. dTAG-47 can induce upregulated expression of some endogenous retrovirus (ERV) genes and is suitable for cancer research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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dTAG-47 | 99.23% | dTAG-47 is a heterobifunctional PROTAC degrader that specifically binds to the FKBP12F36V domain and Cereblon (CRBN). By recruiting the CRBN E3 ubiquitin ligase, dTAG-47 induces ubiquitination and proteasomal degradation of FKBP12F36V-fused Cas9 and tagged KDM5A. dTAG-47 can induce upregulated expression of some endogenous retrovirus (ERV) genes and is suitable for cancer research. | ||||||||||||||||||||
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References
- [1]. Sreekanth V, et al. Chemogenetic System Demonstrates That Cas9 Longevity Impacts Genome Editing Outcomes. ACS central science. 2020 Dec 23;6(12):2228-2237. [Content Brief]
- [2]. Chen H, et al. Histone demethylase enzymes KDM5A and KDM5B modulate immune response by suppressing transcription of endogenous retroviral elements[J]. bioRxiv, 2024.
