dTAG-47
Based on 1 publication(s) in Google Scholar
dTAG-47 is a FKBP12(F36V) PROTAC degrader. dTAG-47 efficiently degrades FKBP12(F36V)-MELK(sg3R) in MELK?/? MDA-MB-468-FKBP12(F36V)-MELK(sg3R) cells. dTAG-47 can be used for the research of basal-like breast cancers (BBC).
(Pink: FKBP12 ligand (HY-114420); Blue: Cereblon ligand (HY-W087383); Black: linker (HY-42773)).
For research use only. We do not sell to patients.
- Purity: 99.23%
- CAS No.: 2265886-81-3
- Formula: C59H73N5O14
- Molecular Weight:1076.24
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Immunology/Inflammation Compound Library
HY-L007
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Anti-Cancer Compound Library
HY-L025
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Autophagy Compound Library
HY-L029
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Anti-Aging Compound Library
HY-L034
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Anti-Breast Cancer Compound Library
HY-L074
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Heterocyclic Compound Library
HY-L138
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PROTAC Library
HY-L151
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Multi-Target Compound Library
HY-L176
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) dTAG-47
MoreAll PROTACs Isoforms
More
Biological Activity
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FKBP12 |
Cereblon |
dTAG-47 (500 nM, 14-72 h) efficiently depletes FKBP12F36V-MELK(sg3R) protein in MELK⁻/⁻ MDA-MB-468-FKBP12F36V-MELK(sg3R) cells[1].
dTAG-47 (500 nM, 9 days) does not impair the growth of MELK⁻/⁻ MDA-MB-468-FKBP12F36V-MELK(sg3R) cells[1].
dTAG-47 (0-3000 nM, 48 h) degrades NL-FKBP-Cas9 in a dose-dependent manner in HEK293T CRBN +/+ cells[2].
dTAG-47 (1 μM, 72 h) modulates DNA repair outcomes by increasing error-prone repair frequency with prolonged Cas9 lifetime in HEK293T cells transfected with NL-FKBP-Cas9, RBM20 gRNA and ssODN[2].
dTAG-47 (0- 1000 nM, 72 h) reduces both on-target and off-target editing at EMX1 loci in a dose-dependent manner and enhances on-target versus off-target specificity in HEK293T cells transfected with NL-FKBP-Cas9 and EMX1 gRNA[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2265886-81-3
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Appearance Solid
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Molecular Weight 1076.24
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Formula C59H73N5O14
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Color Light yellow to green yellow
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SMILES
O=C1N(C2C(NC(CC2)=O)=O)C(C3=CC=C(NCCCCCCCCNC(COC4=C(C=CC=C4)[C@@H](CCC5=CC(OC)=C(C=C5)OC)OC([C@H]6N(CCCC6)C([C@H](C7=CC(OC)=C(C(OC)=C7)OC)CC)=O)=O)=O)C=C31)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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bioRxiv
2025 Nov 30:2025.11.26.690562. PMID: 41394586
Solvent & Solubility
DMSO : 100 mg/mL (92.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Hai-Tsang Huang, et al. MELK is not necessary for the proliferation of basal-like breast cancer cells. Elife. 2017 Sep 19;6:e26693. [Content Brief]
[2]. Sreekanth V, et al. Chemogenetic System Demonstrates That Cas9 Longevity Impacts Genome Editing Outcomes. ACS Cent Sci. 2020 Dec 23;6(12):2228-2237. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9292 mL | 4.6458 mL | 9.2916 mL | 23.2290 mL |
| 5 mM | 0.1858 mL | 0.9292 mL | 1.8583 mL | 4.6458 mL | |
| 10 mM | 0.0929 mL | 0.4646 mL | 0.9292 mL | 2.3229 mL | |
| 15 mM | 0.0619 mL | 0.3097 mL | 0.6194 mL | 1.5486 mL | |
| 20 mM | 0.0465 mL | 0.2323 mL | 0.4646 mL | 1.1615 mL | |
| 25 mM | 0.0372 mL | 0.1858 mL | 0.3717 mL | 0.9292 mL | |
| 30 mM | 0.0310 mL | 0.1549 mL | 0.3097 mL | 0.7743 mL | |
| 40 mM | 0.0232 mL | 0.1161 mL | 0.2323 mL | 0.5807 mL | |
| 50 mM | 0.0186 mL | 0.0929 mL | 0.1858 mL | 0.4646 mL | |
| 60 mM | 0.0155 mL | 0.0774 mL | 0.1549 mL | 0.3872 mL | |
| 80 mM | 0.0116 mL | 0.0581 mL | 0.1161 mL | 0.2904 mL |
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