1. PROTAC Immunology/Inflammation Autophagy Apoptosis
  2. PROTACs FKBP
  3. dTAG-47

dTAG-47, heterobifunctional dTAG molecule, targets mutant FKBP12 (FKBP12F36V). FKBP12F36V serves as a degradation tag (dTAG) and is fused to a protein of interest. dTAG-47 can be used for the research of basal-like breast cancers (BBC).

For research use only. We do not sell to patients.

dTAG-47 Chemical Structure

dTAG-47 Chemical Structure

CAS No. : 2265886-81-3

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5 mg USD 450 In-stock
10 mg USD 790 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

dTAG-47, heterobifunctional dTAG molecule, targets mutant FKBP12 (FKBP12F36V). FKBP12F36V serves as a degradation tag (dTAG) and is fused to a protein of interest. dTAG-47 can be used for the research of basal-like breast cancers (BBC)[1].

Molecular Weight

1076.24

Formula

C59H73N5O14

CAS No.
Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C1N(C2C(NC(CC2)=O)=O)C(C3=CC=C(NCCCCCCCCNC(COC4=C(C=CC=C4)[C@@H](CCC5=CC(OC)=C(C=C5)OC)OC([C@H]6N(CCCC6)C([C@H](C7=CC(OC)=C(C(OC)=C7)OC)CC)=O)=O)=O)C=C31)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (92.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9292 mL 4.6458 mL 9.2916 mL
5 mM 0.1858 mL 0.9292 mL 1.8583 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9292 mL 4.6458 mL 9.2916 mL 23.2290 mL
5 mM 0.1858 mL 0.9292 mL 1.8583 mL 4.6458 mL
10 mM 0.0929 mL 0.4646 mL 0.9292 mL 2.3229 mL
15 mM 0.0619 mL 0.3097 mL 0.6194 mL 1.5486 mL
20 mM 0.0465 mL 0.2323 mL 0.4646 mL 1.1615 mL
25 mM 0.0372 mL 0.1858 mL 0.3717 mL 0.9292 mL
30 mM 0.0310 mL 0.1549 mL 0.3097 mL 0.7743 mL
40 mM 0.0232 mL 0.1161 mL 0.2323 mL 0.5807 mL
50 mM 0.0186 mL 0.0929 mL 0.1858 mL 0.4646 mL
60 mM 0.0155 mL 0.0774 mL 0.1549 mL 0.3872 mL
80 mM 0.0116 mL 0.0581 mL 0.1161 mL 0.2904 mL
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dTAG-47 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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dTAG-47
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