1. Apoptosis
    Immunology/Inflammation
    Autophagy
  2. FKBP
  3. Shield-1

Shield-1 

Cat. No.: HY-112210 Purity: 99.62%
Handling Instructions

Shield-1 is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize the entire fusion protein.

For research use only. We do not sell to patients.

Shield-1 Chemical Structure

Shield-1 Chemical Structure

CAS No. : 914805-33-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 741 In-stock
Estimated Time of Arrival: December 31
1 mg USD 200 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 730 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2700 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3850 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

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Description

Shield-1 is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize the entire fusion protein[1][2].

Molecular Weight

748.90

Formula

C₄₂H₅₆N₂O₁₀

CAS No.

914805-33-7

SMILES

O=C([[email protected]]1N(C([[email protected]](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[[email protected]@H](C3=CC=CC(OCCN4CCOCC4)=C3)CCC5=CC=C(OC)C(OC)=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (333.82 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3353 mL 6.6765 mL 13.3529 mL
5 mM 0.2671 mL 1.3353 mL 2.6706 mL
10 mM 0.1335 mL 0.6676 mL 1.3353 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 25 mg/mL (33.38 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 25 mg/mL (33.38 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.62%

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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Shield-1Shield1Shield 1FKBPFK506-binding proteinInhibitorinhibitorinhibit

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Product name:
Shield-1
Cat. No.:
HY-112210
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