2. PROTAC Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. PROTACs ATM/ATR
  4. Abd110

Abd110 (compound 42i) is a Lenalidomide-based PROTAC ATR kinase degrader. Abd110 selectively decreases ATR and phospho-ATR without affecting related kinases ATM and DNA-PKcs.

For research use only. We do not sell to patients.

Abd110

Abd110 Chemical Structure

CAS No. : 3021581-79-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
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Customer Review

Based on 1 publication(s) in Google Scholar

Abd110 Related Antibodies

Top Publications Citing Use of Products

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ATM ATR TRRAP

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Abd110 (compound 42i) is a Lenalidomide-based PROTAC ATR kinase degrader. Abd110 selectively decreases ATR and phospho-ATR without affecting related kinases ATM and DNA-PKcs[1].

IC50 & Target[1]

ATR

 

Cereblon

 

In Vitro

Abd110 (compound 42i; 0.5-2 μM; 24 h) selectively degrades ATR through the proteasome, dependent on the E3 ubiquitin ligase component cereblon, and without affecting the associated kinases ATM and DNA-PKcs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Abd110 Related Antibodies

Cell Viability Assay[1]

Cell Line: MIA PaCa-2 cells
Concentration: 0.5 μM, 1 μM, and 2 μM
Incubation Time: 24 h
Result: Decreased ATR and p-ATR levels without affecting related checkpoint kinases.
Molecular Weight

790.89

Formula

C41H42N8O7S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=NC(C2=CC=C(S(=O)(NCCCCCC(NCCCC#CC3=CC=CC4=C3CN(C(CC5)C(NC5=O)=O)C4=O)=O)=O)C=C2)=CN=C1N)NC6=CC=CC=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (126.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2644 mL 6.3220 mL 12.6440 mL
5 mM 0.2529 mL 1.2644 mL 2.5288 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2644 mL 6.3220 mL 12.6440 mL 31.6100 mL
5 mM 0.2529 mL 1.2644 mL 2.5288 mL 6.3220 mL
10 mM 0.1264 mL 0.6322 mL 1.2644 mL 3.1610 mL
15 mM 0.0843 mL 0.4215 mL 0.8429 mL 2.1073 mL
20 mM 0.0632 mL 0.3161 mL 0.6322 mL 1.5805 mL
25 mM 0.0506 mL 0.2529 mL 0.5058 mL 1.2644 mL
30 mM 0.0421 mL 0.2107 mL 0.4215 mL 1.0537 mL
40 mM 0.0316 mL 0.1580 mL 0.3161 mL 0.7902 mL
50 mM 0.0253 mL 0.1264 mL 0.2529 mL 0.6322 mL
60 mM 0.0211 mL 0.1054 mL 0.2107 mL 0.5268 mL
80 mM 0.0158 mL 0.0790 mL 0.1580 mL 0.3951 mL
100 mM 0.0126 mL 0.0632 mL 0.1264 mL 0.3161 mL
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Abd110 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Abd1103021581-79-0Abd 110Abd-110PROTACsATM/ATRAtaxia telangiectasia mutatedATM and RAD3 relatedPROTAC ATR kinase degraderLenalidomideCRBN,Inhibitorinhibitorinhibit

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