2. PROTAC Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. PROTACs ATM/ATR
  4. Abd110

Abd110 (compound 42i) is a Lenalidomide-based PROTAC ATR kinase degrader. Abd110 selectively decreases ATR and phospho-ATR without affecting related kinases ATM and DNA-PKcs.

For research use only. We do not sell to patients.

Abd110 Chemical Structure

Abd110 Chemical Structure

CAS No. : 3021581-79-0

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Abd110 Related Antibodies

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Description

Abd110 (compound 42i) is a Lenalidomide-based PROTAC ATR kinase degrader. Abd110 selectively decreases ATR and phospho-ATR without affecting related kinases ATM and DNA-PKcs[1].

IC50 & Target[1]

ATR

 

Cereblon

 

In Vitro

Abd110 (compound 42i; 0.5-2 μM; 24 h) selectively degrades ATR through the proteasome, dependent on the E3 ubiquitin ligase component cereblon, and without affecting the associated kinases ATM and DNA-PKcs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Abd110 Related Antibodies

Cell Viability Assay[1]

Cell Line: MIA PaCa-2 cells
Concentration: 0.5 μM, 1 μM, and 2 μM
Incubation Time: 24 h
Result: Decreased ATR and p-ATR levels without affecting related checkpoint kinases.
Molecular Weight

790.89

Formula

C41H42N8O7S
CAS No.
SMILES

O=C(C1=NC(C2=CC=C(S(=O)(NCCCCCC(NCCCC#CC3=CC=CC4=C3CN(C(CC5)C(NC5=O)=O)C4=O)=O)=O)C=C2)=CN=C1N)NC6=CC=CC=C6
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Abd110 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Abd1103021581-79-0Abd 110Abd-110PROTACsATM/ATRAtaxia telangiectasia mutatedATM and RAD3 relatedPROTAC ATR kinase degraderLenalidomideCRBN,Inhibitorinhibitorinhibit

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