XMD8-92

Name: XMD8-92
Brand: MedChemExpress
SKU: HY-14443
Rating: 5.0 (15 reviews)

Cat. No.: HY-14443 Purity: 99.48%: Data Sheet
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XMD8-92 is a potent ERK5 (BMK1)/BRD4 inhibitor with K_ds of 80 and 190 nM, respectively. XMD8-92 inhibits DCAMKL2, PLK4 and TNK1 with K_ds of 190, 600 and 890 nM, respectively. Anti-cancer activity.

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CAS No. : 1234480-50-2

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10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
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Based on 15 publication(s) in Google Scholar

15 Publications Citing Use of MCE XMD8-92

: XMD8-92 purchased from MedChemExpress. Usage Cited in: Stem Cell Reports. 2018 Oct 9;11(4):929-943. [Abstract]; Immunoblotting of total cell lysates of CML cell lines; tubulin is a loading control; representative images from four independent experiments.

: XMD8-92 purchased from MedChemExpress. Usage Cited in: PLoS One. 2015 Apr 17;10(4):e0125054. [Abstract]; The induction of c-Fos is blocked by inhibition of the ERK5 pathway. 4B12 cells (2.5 × 10⁴) are pretreated with or without BIX02189 or XMD8-92 for 6 hrs and then cultured in the presence of M-CSF (10 ng/mL) for 24 hrs. The expression of c-Fos is measured by Western blot analysis.

: XMD8-92 purchased from MedChemExpress. Usage Cited in: Sci Signal. 2014 Oct 28;7(349):ra102. [Abstract]; Activation of ERK5 in neuroblastoma cell lines expressing activated ALK. (A to C) Immunoblotting for the indicated proteins in neuroblastoma cells CLB-BAR (A), CLB-GE (B), and IMR32 (C) cultured on six-well plates in complete growth medium and treated with inhibitors as indicated for 6 hours alone (A and B) or before (C) stimulation with mAb46 for 30 min.

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•Related Screening Libraries:

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View All CaMK Isoform Specific Products:

View All Isoforms

CaMK II CaMK III/eEF-2K CAMK IV PHK Trio DCAMKL

View All ERK Isoform Specific Products:

View All Isoforms

ERK ERK1 ERK2 ERK5 ERK8

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[1]

BMK1

80 nM (Kd)

BRD4

190 nM (Kd)

DCAMKL1

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	IC₅₀	> 10000 nM Compound: XMD8-92	Inhibition of cell growth in HEK293T cells incubated for 72 hrs by CellTiter-blue reagent based assay Inhibition of cell growth in HEK293T cells incubated for 72 hrs by CellTiter-blue reagent based assay	[PMID: 34710325]
HL-60	IC₅₀	10.59 μM Compound: 4; XMD8-92	Antiproliferative activity against human HL60 cells assessed as reduction in cell viability measured after 24 hrs Antiproliferative activity against human HL60 cells assessed as reduction in cell viability measured after 24 hrs	[PMID: 32078308]
HeLa	IC₅₀	0.24 μM Compound: 18	Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysis Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysis	[PMID: 21412406]
HeLa	IC₅₀	1.5 μM Compound: Chemical probe : XMD8-92	Inhibition of ERK5 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ERK5 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	10 μM Compound: Chemical probe : XMD8-92	Inhibition of TNK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of TNK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	18 μM Compound: Chemical probe : XMD8-92	Inhibition of ACK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ACK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	26 μM Compound: Chemical probe : XMD8-92	Inhibition of RSK1 domain 2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of RSK1 domain 2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	29 μM Compound: Chemical probe : XMD8-92	Inhibition of RSK1 domain 2 K1 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of RSK1 domain 2 K1 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	300 nM Compound: 2; XMD8-92	Inhibition of ERK5 in human HeLa cells incubated for 15 mins prior to ATP addition by KiNativ profiling method Inhibition of ERK5 in human HeLa cells incubated for 15 mins prior to ATP addition by KiNativ profiling method	[PMID: 31212132]
HeLa	IC₅₀	31 μM Compound: Chemical probe : XMD8-92	Inhibition of RSK1 domain 2 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of RSK1 domain 2 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	34 μM Compound: Chemical probe : XMD8-92	Inhibition of PIK4CB in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PIK4CB in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	36 μM Compound: Chemical probe : XMD8-92	Inhibition of PIK4CA in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PIK4CA in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	39 μM Compound: Chemical probe : XMD8-92	Inhibition of FAK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of FAK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	47 μM Compound: Chemical probe : XMD8-92	Inhibition of RSK2 domain 2 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of RSK2 domain 2 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	49 μM Compound: Chemical probe : XMD8-92	Inhibition of RSK2 domain 2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of RSK2 domain 2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: 4; XMD8-92	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs	[PMID: 32078308]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of ABL1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ABL1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of AGK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of AGK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of AKT1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of AKT1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of ALS2CR2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ALS2CR2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of AMPKalpha1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of AMPKalpha1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of AMPKalpha1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of AMPKalpha1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of AMPKalpha1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of AMPKalpha1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of AMPKalpha2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of AMPKalpha2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of ARAF in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ARAF in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of ATM in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ATM in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of ATR in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ATR in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of AURA in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of AURA in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of AURA/AURB/AURC in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of AURA/AURB/AURC in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of AXL in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of AXL in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of BRAF in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of BRAF in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of BRAF in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of BRAF in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CAMK1d in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CAMK1d in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CAMK1d in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CAMK1d in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CAMK2d in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CAMK2d in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CAMK2d in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CAMK2d in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CAMK2g in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CAMK2g in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CAMK2g in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CAMK2g in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CAMKK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CAMKK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CASK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CASK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CDC2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CDC2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CDK10 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CDK10 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CDK2 K1 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CDK2 K1 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CDK2 K1 site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CDK2 K1 site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CDK2 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CDK2 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CDK2 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CDK2 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CDK5 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CDK5 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CDK5 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CDK5 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CDK5/PRKX/PRKY in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CDK5/PRKX/PRKY in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CDK5/PRKX/PRKY in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CDK5/PRKX/PRKY in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CDK7 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CDK7 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CDK8/CDK11 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CDK8/CDK11 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CDK9 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CDK9 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CDK9 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CDK9 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CHED in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CHED in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CHED in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CHED in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CHK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CHK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CHK1 inactive site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CHK1 inactive site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CHK2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CHK2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CK1alpha in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CK1alpha in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CK1g1/g2/g3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CK1g1/g2/g3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CLK3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CLK3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of COT in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of COT in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CRK7 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CRK7 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CSK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CSK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of CSK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of CSK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of EEF2K in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of EEF2K in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of EGFR in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of EGFR in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of EGFR in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of EGFR in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of ERK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ERK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of ERK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ERK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of ERK2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ERK2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of ERK4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ERK4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of EphA2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of EphA2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of EphB4 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of EphB4 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of EphB4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of EphB4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of FER in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of FER in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of FRAP in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of FRAP in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of FYN in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of FYN in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of GCK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of GCK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of GCN2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of GCN2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of GSK3A in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of GSK3A in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of GSK3B isoform 2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of GSK3B isoform 2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of GSK3B isoform 2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of GSK3B isoform 2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of HGK/MINK/TNIK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of HGK/MINK/TNIK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of HGK/MINK/TNIK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of HGK/MINK/TNIK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of IGF1R in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of IGF1R in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of IKKA in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of IKKA in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of IKKB in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of IKKB in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of IKKE/TBK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of IKKE/TBK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of ILK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ILK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of INSR in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of INSR in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of IRAK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of IRAK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of IRAK4 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of IRAK4 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of IRAK4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of IRAK4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of IRE1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of IRE1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of JAK1 domain 2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of JAK1 domain 2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of JAK1 domain 2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of JAK1 domain 2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of JNK1/JNK2/JNK3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of JNK1/JNK2/JNK3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of KHS1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of KHS1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of LATS1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of LATS1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of LATS2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of LATS2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of LOK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of LOK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of LOK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of LOK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of LYN in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of LYN in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP2K1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP2K1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP2K1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP2K1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP2K1/MAP2K2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP2K1/MAP2K2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP2K1/MAP2K2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP2K1/MAP2K2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP2K3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP2K3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP2K3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP2K3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP2K4 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP2K4 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP2K4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP2K4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP2K5 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP2K5 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP2K6 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP2K6 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP2K6 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP2K6 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP2K7 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP2K7 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP3K1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP3K1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP3K2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP3K2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP3K2/MAP3K3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP3K2/MAP3K3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP3K2/MAP3K3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP3K2/MAP3K3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP3K4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP3K4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP3K5 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP3K5 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAP3K5/MAP3K6/MAP3K15 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAP3K5/MAP3K6/MAP3K15 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MARK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MARK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MARK2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MARK2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MARK3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MARK3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MARK3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MARK3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MAST3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MAST3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MASTL in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MASTL in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MET in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MET in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MLK3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MLK3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MLKL in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MLKL in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MLKL in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MLKL in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MPSK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MPSK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MRCKB in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MRCKB in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MSK1 domain 1 K1 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MSK1 domain 1 K1 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MSK1 domain 1 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MSK1 domain 1 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MSK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MSK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MSK1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MSK1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MSK1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MSK1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MST1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MST1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MST1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MST1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MST1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MST1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MST1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MST1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MST2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MST2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MST3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MST3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MST3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MST3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MST4/YSK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MST4/YSK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of MST4/YSK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of MST4/YSK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of NDR1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of NDR1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of NDR2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of NDR2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of NEK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of NEK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of NEK3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of NEK3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of NEK4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of NEK4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of NEK6/7 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of NEK6/7 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of NEK6/7 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of NEK6/7 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of NEK7 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of NEK7 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of NEK7 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of NEK7 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of NEK8 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of NEK8 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of NEK9 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of NEK9 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of NEK9 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of NEK9 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of P38a in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of P38a in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of P38a interaction site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of P38a interaction site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of P38delta/gamma in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of P38delta/gamma in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of P70S6K in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of P70S6K in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of P70S6KB in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of P70S6KB in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PAN3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PAN3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PCTAIRE1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PCTAIRE1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PCTAIRE2/ICK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PCTAIRE2/ICK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PCTAIRE2/PCTAIRE3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PCTAIRE2/PCTAIRE3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PDK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PDK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PEK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PEK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PFTAIRE2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PFTAIRE2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PHKg2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PHKg2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PHKg2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PHKg2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PIK3C2B in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PIK3C2B in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PIK3C3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PIK3C3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PIK4CB in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PIK4CB in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PIP5K2A LIP1 labeling site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PIP5K2A LIP1 labeling site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PIP5K2A LIP1 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PIP5K2A LIP1 site in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PIP5K2A in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PIP5K2A in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PIP5K2A in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PIP5K2A in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PIP5K2B in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PIP5K2B in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PIP5K2C in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PIP5K2C in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PIP5K3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PIP5K3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PITSLRE in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PITSLRE in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PKCalpha/beta in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PKCalpha/beta in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PKCiota in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PKCiota in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PKCtheta in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PKCtheta in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PKCzeta in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PKCzeta in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PKD1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PKD1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PKD2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PKD2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PKD3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PKD3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PKN2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PKN2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PKR in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PKR in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PKR in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PKR in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PLK1 K1 site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PLK1 K1 site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PLK1 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PLK1 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PLK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PLK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PLK1 splice variant in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PLK1 splice variant in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PRKDC in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PRKDC in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PRKDC in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PRKDC in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PRKX/PRKY in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PRKX/PRKY in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PRP4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PRP4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PRPK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PRPK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of PRPK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of PRPK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of ROCK1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ROCK1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of RON in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of RON in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of RSK1 domain 1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of RSK1 domain 1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of RSK1/2/3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of RSK1/2/3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of RSK1/RSK2/RSK3 domain 1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of RSK1/RSK2/RSK3 domain 1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of RSK2 domain 1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of RSK2 domain 1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of RSK2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of RSK2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of SGK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of SGK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of SGK3 K1 site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of SGK3 K1 site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of SGK3 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of SGK3 K2 site in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of SGK3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of SGK3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of SLK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of SLK in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of SLK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of SLK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of SMG1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of SMG1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of SRC/FYN/YES in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of SRC/FYN/YES in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of SRPK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of SRPK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of SRPK1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of SRPK1/2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of TAK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of TAK1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of TAO2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of TAO2 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of TAO3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of TAO3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of TIF1b in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of TIF1b in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of TLK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of TLK1 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of TLK2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of TLK2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of ULK2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ULK2 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of ULK3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ULK3 in human HeLa cells lysate pre incubated for 15 mins followed by ADP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of ULK3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ULK3 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of Wee1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of Wee1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of Wnk1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of Wnk1 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of Wnk1/2/4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of Wnk1/2/4 in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
HeLa	IC₅₀	> 50 μM Compound: Chemical probe : XMD8-92	Inhibition of ZAK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis Inhibition of ZAK in human HeLa cells lysate pre incubated for 15 mins followed by ATP acyl phosphate probe addition and measured after 10 mins by LC-MS/MS analysis	[PMID: 20832753]
MKN-74	IC₅₀	> 50 μM Compound: 4; XMD8-92	Antiproliferative activity against human MKN74 cells assessed as reduction in cell viability measured after 24 hrs Antiproliferative activity against human MKN74 cells assessed as reduction in cell viability measured after 24 hrs	[PMID: 32078308]
MM1.S	IC₅₀	2100 nM Compound: XMD8-92	Inhibition of cell growth in human MM1.S cells incubated for 72 hrs by CellTiter-blue reagent based assay Inhibition of cell growth in human MM1.S cells incubated for 72 hrs by CellTiter-blue reagent based assay	[PMID: 34710325]

In Vitro

XMD8-92 (0-5 Μm; 48 hours) inhibits the proliferation of HMEC and cancer cells^[1].
XMD8-92 effectively inhibits BMK1 activation as well as induces PML’s (promyelocytic leukemia protein) downstream effector, p21. XMD8-92 significantly inhibits basic fibroblast growth factor (bFGF) induced angiogenesis in Matrigel plugs. XMD8-92 significantly induces p21 expression in HeLa and A549 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	HMEC, A549 and HeLa cells
Concentration:	0.16, 0.32, 0.63, 1.25, 2.5 or 5 μM
Incubation Time:	48 hours
Result:	Inhibited the proliferation of HMEC and cancer cells.

In Vivo

XMD8-92 (i.p.; twice a day for 28 days) significantly inhibits the growth of the xenografted human tumors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	HeLa Xenograft Model (6-week-old Nod/Scid mice)^[1]
Dosage:	50 mg/kg
Administration:	I.p.; twice a day for 28 days
Result:	Significantly inhibited the growth of the xenografted human tumors.

Molecular Weight

474.55

Formula

C₂₆H₃₀N₆O₃

CAS No.

1234480-50-2

Appearance

Solid

Color

Off-white to light yellow

SMILES

CN(C1=O)C2=CN=C(N=C2N(C3=C1C=CC=C3)C)NC4=C(C=C(C=C4)N5CCC(CC5)O)OCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (105.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1073 mL	10.5363 mL	21.0726 mL
5 mM	0.4215 mL	2.1073 mL	4.2145 mL
10 mM	0.2107 mL	1.0536 mL	2.1073 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.48%

Select Batch:

Data Sheet (277 KB) SDS (393 KB)

COA (250 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Yang Q, et al. Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein.Cancer Cell. 2010 Sep 14;18(3):258-67. [Content Brief]

[2]. Yang Q, et al. Targeting the BMK1 MAP kinase pathway in cancer therapy. Clin Cancer Res. 2011 Jun 1;17(11):3527-32. [Content Brief]

[3]. Lin EC, et al. ERK5 kinase activity is dispensable for cellular immune response and proliferation. Proc Natl Acad Sci U S A. 2016;113(42):11865-11870. [Content Brief]

[4]. Umapathy G, et al. The kinase ALK stimulates the kinase ERK5 to promote the expression of the oncogene MYCN in neuroblastoma. Sci Signal. 2014 Oct 28;7(349):ra102. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1073 mL	10.5363 mL	21.0726 mL	52.6815 mL
	5 mM	0.4215 mL	2.1073 mL	4.2145 mL	10.5363 mL
	10 mM	0.2107 mL	1.0536 mL	2.1073 mL	5.2681 mL
	15 mM	0.1405 mL	0.7024 mL	1.4048 mL	3.5121 mL
	20 mM	0.1054 mL	0.5268 mL	1.0536 mL	2.6341 mL
	25 mM	0.0843 mL	0.4215 mL	0.8429 mL	2.1073 mL
	30 mM	0.0702 mL	0.3512 mL	0.7024 mL	1.7560 mL
	40 mM	0.0527 mL	0.2634 mL	0.5268 mL	1.3170 mL
	50 mM	0.0421 mL	0.2107 mL	0.4215 mL	1.0536 mL
	60 mM	0.0351 mL	0.1756 mL	0.3512 mL	0.8780 mL
	80 mM	0.0263 mL	0.1317 mL	0.2634 mL	0.6585 mL
	100 mM	0.0211 mL	0.1054 mL	0.2107 mL	0.5268 mL

XMD8-92 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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