1234480-50-2
1234480-50-2
Chemical Structure
XMD8-92
- CAS No.: 1234480-50-2
- Formula:C26H30N6O3
- Molecular Weight:474.55
IUPAC Name: 2-((2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl)amino)-5,11-dimethyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one
InChIKey: QAPAJIZPZGWAND-UHFFFAOYSA-N
SMILES: CN(C1=O)C2=CN=C(N=C2N(C3=C1C=CC=C3)C)NC4=C(C=C(C=C4)N5CCC(CC5)O)OCC
Biological Activity: XMD8-92 is a potent ERK5 (BMK1)/BRD4 inhibitor with Kds of 80 and 190 nM, respectively. XMD8-92 inhibits DCAMKL2, PLK4 and TNK1 with Kds of 190, 600 and 890 nM, respectively. Anti-cancer activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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XMD8-92 | 99.48% | XMD8-92 is a potent ERK5 (BMK1)/BRD4 inhibitor with Kds of 80 and 190 nM, respectively. XMD8-92 inhibits DCAMKL2, PLK4 and TNK1 with Kds of 190, 600 and 890 nM, respectively. Anti-cancer activity. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.82
HY-184975ERK5 ligand-2 -
Similarity Score 0.81
HY-14403ERK5-IN-1 -
Similarity Score 0.80
HY-15812XMD-12 -
Similarity Score 0.74
HY-181968JWG-045 -
Similarity Score 0.72
HY-135985DCLK1-IN-1 -
Similarity Score 0.71
HY-15811XMD8-87 -
Similarity Score 0.68
HY-101243XMD16-5 -
Similarity Score 0.68
HY-10875LRRK2-IN-1 -
Similarity Score 0.66
HY-144993PI3Kδ/γ-IN-1 -
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References
- [1]. Yang Q, et al. Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein.Cancer Cell. 2010 Sep 14;18(3):258-67. [Content Brief]
- [2]. Yang Q, et al. Targeting the BMK1 MAP kinase pathway in cancer therapy. Clin Cancer Res. 2011 Jun 1;17(11):3527-32. [Content Brief]
