2. MAPK/ERK Pathway Stem Cell/Wnt Apoptosis
  3. ERK Ferroptosis
  4. JWG-045

JWG-045 is a selective ERK5 inhibitor. JWG-045 exhibits unique ferroptosis-resistant activity independent of ERK5 inhibition. JWG-045 can be used in breast cancer research.

For research use only. We do not sell to patients.

JWG-045

JWG-045 Chemical Structure

CAS No. : 1234480-61-5

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Description

JWG-045 is a selective ERK5 inhibitor. JWG-045 exhibits unique ferroptosis-resistant activity independent of ERK5 inhibition. JWG-045 can be used in breast cancer research[1].

IC50 & Target[1]

ERK5

 

In Vitro

JWG-045 (3 μM; 24 h) reduces cell density modestly in BT474 cells and protects both BT474 and MDA-MB-231 breast cancer cells from RSL3-induced ferroptotic cell death[1].
JWG-045 (3 μM; 24 h) protects ERK5-silenced MDA-MB-231 triple-negative breast cancer cells from RSL3-induced ferroptosis independently of ERK5 expression[1].
JWG-045 (3 μM; 6 days) reduces cell density in Trastuzumab (HY-P9907)-resistant BT474 breast cancer cells and restores sensitivity to Trastuzumab[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JWG-045 Related Antibodies

Cell Viability Assay[1]

Cell Line: BT474 luminal B breast cancer cells, MDA-MB-231 triple-negative breast cancer cells
Concentration: 3 μM (single treatment; pre-incubated then combined with RSL3)
Incubation Time: 24 h (single treatment; total incubation with RSL3); 20 h (live-cell imaging)
Result: Caused a modest, statistically significant reduction in BT474 cell density.
Reduced RSL3-induced cytotoxicity in both BT474 and MDA-MB-231 cells, significantly increasing cell density compared to RSL3 alone.
Prevented the time-dependent decrease in BT474 cell confluency induced by RSL3 over 20 hours.

Cell Viability Assay[1]

Cell Line: ERK5-silenced MDA-MB-231 triple-negative breast cancer cells
Concentration: 3 μM (alone; combined with RSL3)
Incubation Time: 24 h
Result: Blocked RSL3-induced ferroptotic death in both control and ERK5-silenced MDA-MB-231 cells, significantly increasing cell density compared to RSL3 alone.

Cell Proliferation Assay[1]

Cell Line: Trastuzumab-resistant BT474 breast cancer cells
Concentration: 3 μM (alone; combined with Trastuzumab)
Incubation Time: 6 days
Result: Reduced BT474 cell density.
Restored the growth inhibitory effect of trastuzumab in Trastuzumab-resistant BT474 cells to the level achieved by Trastuzumab monotherapy in parental BT474 cells.
Molecular Weight

487.60

Formula

C27H33N7O2
CAS No.
SMILES

O=C(N(C1=CN=C(N=C12)NC3=CC=C(C=C3OC)N4CCN(CC4)C)C)C5=CC=CC=C5N2C(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JWG-045 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JWG-0451234480-61-5JWG045JWG 045ERKFerroptosisExtracellular signal regulated kinasesferroptosisMDA-MB-231 breast cancer cellsBRD4SUM159PT triple-negative breast cancer cellsLRRK2HeLa cervical cancer cellsbreast cancer cellsERK5DCLKBT474 cellsInhibitorinhibitorinhibit

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