1380087-89-7
1380087-89-7
Chemical Structure
Pelabresib
Synonym(s): CPI-0610
- CAS No.: 1380087-89-7
- Formula:C20H16ClN3O2
- Molecular Weight:365.81
IUPAC Name: (S)-2-(6-(4-chlorophenyl)-1-methyl-4H-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide
InChIKey: GCWIQUVXWZWCLE-INIZCTEOSA-N
SMILES: O=C(N)C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C3=CC=CC=C3C4=C1ON=C4C
Biological Activity: Pelabresib (CPI-0610) is a potent, selective, orally active and cell-active BET inhibitor. Pelabresib inhibits BRD4-BD1 with an IC50 of 39 nM, and with an EC50 value of 0.18 μM for MYC[1].
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Pelabresib | 99.95% | Pelabresib (CPI-0610) is a potent, selective, orally active and cell-active BET inhibitor. Pelabresib inhibits BRD4-BD1 with an IC50 of 39 nM, and with an EC50 value of 0.18 μM for MYC. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.90
HY-12863BCPI-0610 carboxylic acid -
Similarity Score 0.85
HY-104072BRD4-IN-3 -
Similarity Score 0.75
HY-103036BET bromodomain-IN-5 -
Similarity Score 0.50
HY-14229RTGR5 Receptor Agonist (Standard) -
Similarity Score 0.49
HY-112813TUG-1375 -
Similarity Score 0.49
HY-100696PNZ5 -
Similarity Score 0.48
HY-121698GW694481 -
Similarity Score 0.48
HY-107442RPROTAC BRD4-binding moiety 1 (Standard) -
Similarity Score 0.48
HY-150941BRD4 ligand 2 -
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