3094772-96-7
3094772-96-7
Chemical Structure
CZL-149
- CAS No.: 3094772-96-7
- Formula:C23H23F3N4O3
- Molecular Weight:460.45
InChIKey: KZLPUNDBZNDKMF-UHFFFAOYSA-N
SMILES: O=C1C2=C(C(C3=CC4=C(N=C(C5CCOCC5)N4CCOC(F)(F)F)C=C3)=CN1C)C=CN2
Biological Activity: CZL-149 is an orally active dual BET and p300/CBP bromodomains inhibitor with IC50s of 13 nM and 10.5 nM for BED4 BD1 and p300, respectively. CZL-149 reduces c-Myc and H3K27Ac levels. CZL-149 has good drug-like properties and metabolic characteristics, as well as good safety. CZL-149 can be used for the study of multiple myeloma[1].
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CZL-149 | CZL-149 is an orally active dual BET and p300/CBP bromodomains inhibitor with IC50s of 13 nM and 10.5 nM for BED4 BD1 and p300, respectively. CZL-149 reduces c-Myc and H3K27Ac levels. CZL-149 has good drug-like properties and metabolic characteristics, as well as good safety. CZL-149 can be used for the study of multiple myeloma. | |||||||||||||||||||||
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References
Keywords
