2. Vitamin D Related/Nuclear Receptor Epigenetics
  3. Androgen Receptor Epigenetic Reader Domain
  4. AR/BRD4 RIPTAC-1

AR/BRD4 RIPTAC-1 (Compound II-5) is an orally active Regulatory-inducible proximity-targeting chimera (RIPTAC). AR/BRD4 RIPTAC-1 induces the formation of a stable ternary complex between the androgen receptor (AR) and BRD4, thereby blocking BRD4 function. AR/BRD4 RIPTAC-1 inhibits the growth and proliferation of tumor cells. AR/BRD4 RIPTAC-1 holds promise for use in prostate cancer research.

For research use only. We do not sell to patients.

AR/BRD4 RIPTAC-1

AR/BRD4 RIPTAC-1 Chemical Structure

CAS No. : 3083307-42-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
1 mg In-stock
5 mg In-stock
10 mg In-stock
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100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of AR/BRD4 RIPTAC-1:

AR/BRD4 RIPTAC-1 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

AR/BRD4 RIPTAC-1 (Compound II-5) is an orally active Regulatory-inducible proximity-targeting chimera (RIPTAC). AR/BRD4 RIPTAC-1 induces the formation of a stable ternary complex between the androgen receptor (AR) and BRD4, thereby blocking BRD4 function. AR/BRD4 RIPTAC-1 inhibits the growth and proliferation of tumor cells. AR/BRD4 RIPTAC-1 holds promise for use in prostate cancer research[1].

IC50 & Target[1]

BRD4

 

In Vitro

AR/BRD4 RIPTAC-1 (72 h) inhibits the growth of T47D cells with a GI50 of less than 0.5 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AR/BRD4 RIPTAC-1 Related Antibodies
In Vivo

AR/BRD4 RIPTAC-1 (p.o.; 7 days) inhibits tumor growth in CB17.SCID mice bearing VCaP tumors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

907.09

Formula

C50H54N10O5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N#CC1=C(OC)C=C(O[C@@H]2C(C)(C)[C@@H](NC(C3=CN=C(N4CCC5(CC(OC6=CC=C(C7=N[C@@H](CC8=NC=CO8)C9=NN=C(C)N9C%10=C7C(C)=C(C)S%10)C=C6)C5)CC4)N=C3)=O)C2(C)C)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (55.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1024 mL 5.5121 mL 11.0243 mL
5 mM 0.2205 mL 1.1024 mL 2.2049 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1024 mL 5.5121 mL 11.0243 mL 27.5607 mL
5 mM 0.2205 mL 1.1024 mL 2.2049 mL 5.5121 mL
10 mM 0.1102 mL 0.5512 mL 1.1024 mL 2.7561 mL
15 mM 0.0735 mL 0.3675 mL 0.7350 mL 1.8374 mL
20 mM 0.0551 mL 0.2756 mL 0.5512 mL 1.3780 mL
25 mM 0.0441 mL 0.2205 mL 0.4410 mL 1.1024 mL
30 mM 0.0367 mL 0.1837 mL 0.3675 mL 0.9187 mL
40 mM 0.0276 mL 0.1378 mL 0.2756 mL 0.6890 mL
50 mM 0.0220 mL 0.1102 mL 0.2205 mL 0.5512 mL
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AR/BRD4 RIPTAC-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AR/BRD4 RIPTAC-13083307-42-7Androgen ReceptorEpigenetic Reader Domainantiproliferative agentInhibitorinhibitorinhibit

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