AR/BRD4 RIPTAC-1
Based on 1 Customer Validation
AR/BRD4 RIPTAC-1 (Compound II-5) is an orally active Regulatory-inducible proximity-targeting chimera (RIPTAC). AR/BRD4 RIPTAC-1 induces the formation of a stable ternary complex between the androgen receptor (AR) and BRD4, thereby blocking BRD4 function. AR/BRD4 RIPTAC-1 inhibits the growth and proliferation of tumor cells. AR/BRD4 RIPTAC-1 holds promise for use in prostate cancer research.
For research use only. We do not sell to patients.
- CAS No.: 3083307-42-7
- Formula: C50H54N10O5S
- Molecular Weight:907.09
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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BRD4 |
AR/BRD4 RIPTAC-1 (72 h) inhibits the growth of T47D cells with a GI50 of less than 0.5 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3083307-42-7
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Appearance Solid
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Molecular Weight 907.09
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Formula C50H54N10O5S
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Color White to off-white
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SMILES
N#CC1=C(OC)C=C(O[C@@H]2C(C)(C)[C@@H](NC(C3=CN=C(N4CCC5(CC(OC6=CC=C(C7=N[C@@H](CC8=NC=CO8)C9=NN=C(C)N9C%10=C7C(C)=C(C)S%10)C=C6)C5)CC4)N=C3)=O)C2(C)C)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 50 mg/mL (55.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1024 mL | 5.5121 mL | 11.0243 mL | 27.5607 mL |
| 5 mM | 0.2205 mL | 1.1024 mL | 2.2049 mL | 5.5121 mL | |
| 10 mM | 0.1102 mL | 0.5512 mL | 1.1024 mL | 2.7561 mL | |
| 15 mM | 0.0735 mL | 0.3675 mL | 0.7350 mL | 1.8374 mL | |
| 20 mM | 0.0551 mL | 0.2756 mL | 0.5512 mL | 1.3780 mL | |
| 25 mM | 0.0441 mL | 0.2205 mL | 0.4410 mL | 1.1024 mL | |
| 30 mM | 0.0367 mL | 0.1837 mL | 0.3675 mL | 0.9187 mL | |
| 40 mM | 0.0276 mL | 0.1378 mL | 0.2756 mL | 0.6890 mL | |
| 50 mM | 0.0220 mL | 0.1102 mL | 0.2205 mL | 0.5512 mL |
AR/BRD4 RIPTAC-1 Related Classifications
HY-176521 Related Classifications
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