2. Epigenetics
    Apoptosis
  3. Epigenetic Reader Domain
    Apoptosis
  4. Mivebresib

Mivebresib  (Synonyms: ABBV-075)

Cat. No.: HY-100015 Purity: 99.42%
COA Handling Instructions

Mivebresib (ABBV-075) est un inhibiteur puissant et oralement actif de bromodomaine et un bromodomaine du domaine extraterminal (BET). Mivebresib se lie à BRD4 avec un Ki de 1,5 nM.

Mivebresib (ABBV-075) ist ein potenter und oral aktiver Inhibitor der bromodomain and extraterminal domain (BET) bromodomain. Mivebresib bindet an BRD4 mit einem Ki von 1.5 nM.

Mivebresib (ABBV-075) is a potent and orally active bromodomain and extraterminal domain (BET) bromodomain inhibitor. Mivebresib binds to BRD4 with a Ki of 1.5 nM.

For research use only. We do not sell to patients.

Mivebresib Chemical Structure

Mivebresib Chemical Structure

CAS No. : 1445993-26-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 133 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 133 In-stock
Solid
2 mg USD 106 In-stock
5 mg USD 132 In-stock
10 mg USD 198 In-stock
25 mg USD 330 In-stock
50 mg USD 594 In-stock
100 mg USD 990 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 8 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Mivebresib purchased from MCE. Usage Cited in: Cell Death Dis. 2019 Jul 19;10(8):557.   [Abstract]

    BET inhibitors reduce IDO1 transcription.The protein levels of IDO1 are determined by RT-qPCR and western blotting, respectively.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Mivebresib (ABBV-075) is a potent and orally active bromodomain and extraterminal domain (BET) bromodomain inhibitor. Mivebresib binds to BRD4 with a Ki of 1.5 nM[1].

    IC50 & Target

    IC50: 1.5 nM (BRD4)[1]
    In Vitro

    Mivebresib inhibit DHT-stimulated transcription of AR target genes without significant effect on AR protein expression. In addition to blocking the transcription activation downstream of AR, Mivebresib is also a potent inhibitor of MYC and the TMPRSS2-ETS fusion proteins[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    459.47

    Appearance

    Solid

    Formula

    C22H19F2N3O4S
    CAS No.
    SMILES

    CCS(=O)(NC1=CC=C(OC2=CC=C(F)C=C2F)C(C3=CN(C)C(C4=C3C=CN4)=O)=C1)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (217.64 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1764 mL 10.8821 mL 21.7642 mL
    5 mM 0.4353 mL 2.1764 mL 4.3528 mL
    10 mM 0.2176 mL 1.0882 mL 2.1764 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (5.44 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (5.44 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.44 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation
    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    Mivebresib1445993-26-9ABBV-075ABBV075ABBV 075Epigenetic Reader DomainApoptosisInhibitorinhibitorinhibit

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