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  3. NI-42

NI-42 

Cat. No.: HY-101121 Purity: 99.79%
Handling Instructions

NI-42 (compound 13-d), a structurally orthogonal chemical probe for the BRPFs, is a biased, potent inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/940 nM) with excellent selectivity over nonclass IV BRD proteins.

For research use only. We do not sell to patients.

NI-42 Chemical Structure

NI-42 Chemical Structure

CAS No. : 1884640-99-6

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5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 130 In-stock
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25 mg USD 260 In-stock
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50 mg USD 400 In-stock
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100 mg USD 630 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

NI-42 (compound 13-d), a structurally orthogonal chemical probe for the BRPFs, is a biased, potent inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/940 nM) with excellent selectivity over nonclass IV BRD proteins[1].

IC50 & Target

BRPF1

7.9 nM (IC50)

BRPF2

48 nM (IC50)

BRPF3

260 nM (IC50)

BRPF1

40 nM (Kd)

BRPF2

210 nM (Kd)

BRPF3

940 nM (Kd)

BRD4 (BD1)

4500 nM (IC50)

BRD7

82 nM (IC50)

BRD9

310 nM (IC50)

BRD9

1130 nM (Kd)

In Vitro

NI-42 shows IC50s of 82, 310, and 4500 nM for BRD7, BRD9, and BRD4 (BD1), respectively, and has a Kd of 1130 nM for BRD9[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

353.40

Formula

C18H15N3O3S

CAS No.
SMILES

O=S(C1=CC=C(C#N)C=C1)(NC2=CC=C(N(C)C(C(C)=C3)=O)C3=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (282.97 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8297 mL 14.1483 mL 28.2965 mL
5 mM 0.5659 mL 2.8297 mL 5.6593 mL
10 mM 0.2830 mL 1.4148 mL 2.8297 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.07 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (7.07 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are available by MCE.
References

Purity: 99.79%

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NI-42
Cat. No.:
HY-101121
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