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  3. GSK9311 hydrochloride

GSK9311 hydrochloride 

Cat. No.: HY-100729A
Handling Instructions

GSK9311 hydrochloride, a less active analogue of GSK6853, can be used as a negative control. GSK9311 hydrochloride inhibits BRPF bromodomain with pIC50 values of 6.0 and 4.3 for BRPF1 and BRPF2, respectively.

For research use only. We do not sell to patients.

GSK9311 hydrochloride Chemical Structure

GSK9311 hydrochloride Chemical Structure

CAS No. : 2253733-09-2

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Description

GSK9311 hydrochloride, a less active analogue of GSK6853, can be used as a negative control. GSK9311 hydrochloride inhibits BRPF bromodomain with pIC50 values of 6.0 and 4.3 for BRPF1 and BRPF2, respectively[1].

IC50 & Target[1]

BRPF1

6.0 (pIC50)

BRPF2

4.3 (pIC50)

In Vitro

GSK6853 is a potent (300 pM), soluble, cell active (20 nM), and highly selective inhibitor of the BRPF1 bromodomain, and demonstrates properties suitable for cellular and in vivo studies. GSK6853 is a less active analogue of GSK6853 in which the 5-amide is alkylated[1].

Molecular Weight

474.00

Formula

C₂₄H₃₂ClN₅O₃

CAS No.

2253733-09-2

SMILES

[H]Cl.C[[email protected]@H]1CNCCN1C2=C(N(CC)C(C3=CC=CC=C3OC)=O)C=C(C(N4C)=C2)N(C)C4=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

GSK9311GSK 9311GSK-9311Epigenetic Reader DomainanaloguebromodomainnegativecontrolprobeepigeneticInhibitorinhibitorinhibit

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GSK9311 hydrochloride
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HY-100729A
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