1672684-68-2
1672684-68-2
Chemical Structure
MS402
- CAS No.: 1672684-68-2
- Formula:C20H19ClN2O3
- Molecular Weight:370.83
IUPAC Name: 3-chloro-N-(4-methoxyphenyl)-4-((2-methyl-3-oxocyclopent-1-en-1-yl)amino)benzamide
InChIKey: VZTVTSICPINUNG-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(OC)C=C1)C2=CC=C(NC3=C(C)C(CC3)=O)C(Cl)=C2
Biological Activity: MS402 is a BD1-selective BET BrD inhibitor with Kis of 77 nM, 718 nM, 110 nM, 200 nM, 83 nM, and 240 nM for BRD4(BD1), BRD4(BD2), BRD3(BD1), BRD3(BD2), BRD2(BD1) and BRD2(BD2), respectively. MS402 blocks Th17 cell differentiation and ameliorates colitis in mice[1].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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MS402 | 98.36% | MS402 is a BD1-selective BET BrD inhibitor with Kis of 77 nM, 718 nM, 110 nM, 200 nM, 83 nM, and 240 nM for BRD4(BD1), BRD4(BD2), BRD3(BD1), BRD3(BD2), BRD2(BD1) and BRD2(BD2), respectively. MS402 blocks Th17 cell differentiation and ameliorates colitis in mice. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.58
HY-W011774N-(p-Chlorobenzoyl)-p-anisidine -
Similarity Score 0.55
HY-158412BT317 -
Similarity Score 0.54
HY-165245SBI-183 -
Similarity Score 0.53
HY-129991JNJ-17166864 -
Similarity Score 0.53
HY-121843Ronactolol -
Similarity Score 0.53
HY-111086DG70 -
Similarity Score 0.53
HY-157314HDAC6-IN-27 -
Similarity Score 0.52
HY-161276BFC1108 -
Similarity Score 0.52
HY-121315BRD4097 -
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