HDAC6-IN-27
HDAC6-IN-27 (compound 8C) is a HDAC inhibitor with IC50 vales of 15.9 nM 136.5 nM and 6180.2 nM for HDAC6, HDAC8 and HDAC1, respectively. HDAC6-IN-27 shows potent antiparasitic effects.
For research use only. We do not sell to patients.
- CAS No.: 2758023-91-3
- Formula: C15H15N3O4
- Molecular Weight:301.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Parasite Isoforms
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Biological Activity
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HDAC6 15.9 nM (IC50) |
HDAC8 136.5 nM (IC50) |
HDAC6 6180.2 nM (IC50) |
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
22.28 μM
Compound: 8c
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Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
|
[PMID: 33668008] |
| Jurkat | IC50 |
8.03 μM
Compound: 8c
|
Cytotoxicity against human Jurkat cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human Jurkat cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
|
[PMID: 33668008] |
| MCF7 | IC50 |
>50 μM
Compound: 8c
|
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
|
[PMID: 33668008] |
| NAMALVA | IC50 |
4.79 μM
Compound: 8c
|
Cytotoxicity against human NAMALVA cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human NAMALVA cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
|
[PMID: 33668008] |
Chemical Information
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CAS No. 2758023-91-3
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Molecular Weight 301.30
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Formula C15H15N3O4
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SMILES
O=C(C1=CC=C(NC(NC2=CC=C(OC)C=C2)=O)C=C1)NO
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)