JQ-1 (carboxylic acid)-amine-PEG8-cyanogen
JQ-1 (carboxylic acid)-amine-PEG8-cyanogen is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for BRD4 (HY-78695) and a PROTAC linker, which recruits E3 ligases. JQ-1 (carboxylic acid)-amine-PEG8-cyanogen can be used for the synthesis of PROTAC BET Degrader-14 (HY-179588 ).
For research use only. We do not sell to patients.
- Formula: C38H52ClN5O9S
- Molecular Weight:790.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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BRD2 |
BRD3 |
BRD4 |
In Vitro
BRD4 PROTACs contain two different ligands connected by a linker; one is an E3 ligase ligand (SJ1008066) (HY-149452), and the other is for Ligands of BRD4 target protein (JQ-1 (carboxylic acid)) (HY-78695). PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 790.37
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Formula C38H52ClN5O9S
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SMILES
O=C(C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C(C(C)=C(C)S3)=C3N4C1=NN=C4C)NCCOCCOCCOCCOCCOCCOCCOCCOCC#C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JQ-1 (carboxylic acid)-amine-PEG8-cyanogen Related Classifications
HY-179589 Related Classifications
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