2. PROTAC Epigenetics
  3. Target Protein Ligand-Linker Conjugates Epigenetic Reader Domain
  4. JQ-1 (carboxylic acid)-amine-PEG8-cyanogen

JQ-1 (carboxylic acid)-amine-PEG8-cyanogen is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for BRD4 (HY-78695) and a PROTAC linker, which recruits E3 ligases. JQ-1 (carboxylic acid)-amine-PEG8-cyanogen can be used for the synthesis of PROTAC BET Degrader-14 (HY-179588 ).

For research use only. We do not sell to patients.

JQ-1 (carboxylic acid)-amine-PEG8-cyanogen

JQ-1 (carboxylic acid)-amine-PEG8-cyanogen Chemical Structure

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JQ-1 (carboxylic acid)-amine-PEG8-cyanogen Related Antibodies

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Description

JQ-1 (carboxylic acid)-amine-PEG8-cyanogen is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for BRD4 (HY-78695) and a PROTAC linker, which recruits E3 ligases. JQ-1 (carboxylic acid)-amine-PEG8-cyanogen can be used for the synthesis of PROTAC BET Degrader-14 (HY-179588 )[1].

IC50 & Target

BRD2

 

BRD3

 

BRD4

 

In Vitro

BRD4 PROTACs contain two different ligands connected by a linker; one is an E3 ligase ligand (SJ1008066) (HY-149452), and the other is for Ligands of BRD4 target protein (JQ-1 (carboxylic acid)) (HY-78695). PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JQ-1 (carboxylic acid)-amine-PEG8-cyanogen Related Antibodies
Molecular Weight

790.37

Formula

C38H52ClN5O9S
SMILES

O=C(C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C(C(C)=C(C)S3)=C3N4C1=NN=C4C)NCCOCCOCCOCCOCCOCCOCCOCCOCC#C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JQ-1 (carboxylic acid)-amine-PEG8-cyanogen Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JQ-1 (carboxylic acid)-amine-PEG8-cyanogenTarget Protein Ligand-Linker ConjugatesEpigenetic Reader DomainPROTACUbiquitin-proteasome systemUPSc-MycRUNX2KRT14Inhibitorinhibitorinhibit

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Product Name:
JQ-1 (carboxylic acid)-amine-PEG8-cyanogen
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HY-179589
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