1243583-85-8
Chemical Structure
MG 149
Synonym(s): Tip60 HAT inhibitor
- CAS No.: 1243583-85-8
- Formula:C22H28O3
- Molecular Weight:340.46
IUPAC Name: 2-(4-heptylphenethyl)-6-hydroxybenzoic acid
InChIKey: WBHQYBZRTAEHRR-UHFFFAOYSA-N
SMILES: O=C(O)C1=C(O)C=CC=C1CCC2=CC=C(CCCCCCC)C=C2
Biological Activity: MG149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50 = 47 uM); little potent for PCAF and p300 (IC50 >200 uM). MG 149 inhibits KAT8 and blocks PINK1 kinase activity. MG149 inhibits the phosphorylation of Parkin and ubiquitin, thereby suppressing the initiation of PINK1-dependent mitophagy. MG 149 can reverse chronic restraint stress (CRS) induced hypertension and related molecular changes. MG 149 commonly used in research on diseases such as hypertension and Parkinson's disease[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MG 149 | 99.60% | MG149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50 = 47 uM); little potent for PCAF and p300 (IC50 >200 uM). MG 149 inhibits KAT8 and blocks PINK1 kinase activity. MG149 inhibits the phosphorylation of Parkin and ubiquitin, thereby suppressing the initiation of PINK1-dependent mitophagy. MG 149 can reverse chronic restraint stress (CRS) induced hypertension and related molecular changes. MG 149 commonly used in research on diseases such as hypertension and Parkinson's disease. | ||||||||||||||||||||
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- [1]. Ghizzoni M, et al. 6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site. Eur J Med Chem. 2012 Jan;47(1):337-44. [Content Brief]
- [2]. de Talhouët C, et al. KAT8 compound inhibition inhibits the initial steps of PINK1-dependant mitophagy. Sci Rep. 2024 May 22;14(1):11721. [Content Brief]
- [3]. Wang Y, et al. TIP60 mediates stress-induced hypertension via promoting glutamatedmPFC-to-vCA1 release. Clin Exp Hypertens. 2023 Dec 31;45(1):2259130. [Content Brief]
Keywords
