1. Metabolic Enzyme/Protease
  2. E1/E2/E3 Enzyme
  3. Ginkgolic Acid

Ginkgolic Acid  (Synonyms: Ginkgolic acid (15:1); Ginkgolic acid I; Romanicardic acid)

Cat. No.: HY-N0077 Purity: 99.92%
COA Handling Instructions

Ginkgolic Acid is a natural compound that inhibits SUMOylation with an IC50 of 3.0 μM in in vitro assay.

For research use only. We do not sell to patients.

Ginkgolic Acid Chemical Structure

Ginkgolic Acid Chemical Structure

CAS No. : 22910-60-7

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 225 In-stock
Solution
10 mM * 1 mL in DMSO USD 225 In-stock
Solid
1 mg USD 97 In-stock
5 mg USD 205 In-stock
10 mg USD 337 In-stock
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Customer Review

Based on 11 publication(s) in Google Scholar

Other Forms of Ginkgolic Acid:

Top Publications Citing Use of Products

    Ginkgolic Acid purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2018 Apr 15;345:1-9.  [Abstract]

    Ginkgolic acid (GA) reduces cardiac fibrosis and inflammation in ventricular tissue of MI mice. SUMO-1 measured with Western blot. GA: 50 mg/kg per day.
    • Biological Activity

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    Description

    Ginkgolic Acid is a natural compound that inhibits SUMOylation with an IC50 of 3.0 μM in in vitro assay.

    IC50 & Target

    IC50: 3.0 μM (SUMOylation)[1]

    In Vitro

    Ginkgolic acid inhibits the in vitro SUMOylation of RanGAP1-C2 with the IC50 values of 3.0 μM. The level of SUMOylated p53 is markedly reduced by the ginkgolic acid treatment. Importantly, ginkgolic acid does not affect protein ubiquitination in cells. Ginkgolic acid inhibits the binding between E1 and GA-BODIPY in a dose-dependent manner[1]. Ginkgolic acid (31.2 μg/mL) inhibits HIV protease activity by 60%, compared with the negative control, and the effect is concentration-dependent. Ginkgolic acid treatment (50 and 100 μg/mL) effectively inhibits HIV infection in human PBMC cells. Ginkgolic acid at the concentrations up to 150 μg/mL does not cause any significant cytotoxicity in Jurkat cells[2]. GA only inhibits the growth of tumorogenic cell lines in a both dose- and time-dependent manner. Tumor cells are treated with GA for 72 h, 70.53±4.54% Hep-2 and 63.5±7.2% Tca8113 cells are retarded at GO/G1 phase, and the percentage of apoptosis is 40.4±1.58 and 38.4±1.7%, respectively. GA-treated activated caspase-3 downregulates the expression of anti-apoptotic Bcl-2 protein and upregulates the expression of pro-apoptotic Bax protein, eventually leading to a decrease in the Bcl-2/Bax ratio in tumor cellsin human PBMC cells. Ginkgolic acid at the concentrations up to 150 μg/mL does not cause any significant cytotoxicity in Jurkat cells[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    346.50

    Formula

    C22H34O3

    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(O)C1=C(CCCCCCC/C=C\CCCCCC)C=CC=C1O

    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (288.60 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.8860 mL 14.4300 mL 28.8600 mL
    5 mM 0.5772 mL 2.8860 mL 5.7720 mL
    10 mM 0.2886 mL 1.4430 mL 2.8860 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.75 mg/mL (7.94 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.75 mg/mL (7.94 mM); Clear solution

    *All of the co-solvents are available by MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.92%

    References
    Cell Assay
    [2]

    Jurkat cells (106 cells/mL) are cultured in the RPMI medium with or without different concentrations of ginkgolic acid for 48 hours to test the cytotoxicity of ginkgolic acid. The cytotoxicity of ginkgolic acid is determined using a tetrazolium compound (MTS) and an electron coupling reagent (PMS). MTS is chemically reduced by cells into formazan, which is soluble in the tissue culture medium. The measurement of the absorbance of the formazan can be carried out using 96 well microplates at 492 nm. Since the production of formazan is proportional to the number of living cells, the intensity of the produced color is a good indication of the viability of the cells.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References
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    Ginkgolic Acid Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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