1. Metabolic Enzyme/Protease
    Apoptosis
  2. Glucosidase
    Apoptosis
  3. Malabaricone B

Malabaricone B 

Cat. No.: HY-N8517 Purity: ≥99.0%
Handling Instructions

Malabaricone B, a naturally occurring plant phenolic, is an orally active α-glucosidase inhibitor with an IC50 of 63.7 µM. Malabaricone B has anticancer, antimicrobial, anti-oxidation and antidiabetic activities.

For research use only. We do not sell to patients.

Malabaricone B Chemical Structure

Malabaricone B Chemical Structure

CAS No. : 63335-24-0

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Description

Malabaricone B, a naturally occurring plant phenolic, is an orally active α-glucosidase inhibitor with an IC50 of 63.7 µM. Malabaricone B has anticancer, antimicrobial, anti-oxidation and antidiabetic activities[1][2][3].

In Vitro

Malabaricone B shows selective toxicity to human lung cancer (A549), malignant melanoma (A375) and T cell leukemia (Jurkat) cell lines, without showing toxicity to human normal intestinal (INT407), human kidney (HEK293) and lung fibroblast (WI-38) cells. Among the chosen cancer cell lines, Malabaricone B shows maximum cytotoxicity to the A549 cells (IC50 = 8.1 μM), which is significantly better than that of curcumin (IC50 = 26.7 μM)[1].
The Malabaricone B-induced apoptosis is mediated by an increase in the intracellular reactive oxygen species (ROS). Malabaricone B (2.5, 5, 10 and 20 µM) increases the BAX level while simultaneously decreasing the BCL-2 and BCL-XL levels in the A549 cells, triggering the mitochondrial apoptotic pathway as revealed from the release of cytochrome c, and the activation of caspase-9 and caspase-3[1].
Malabaricone B exhibits a good level of antimicrobial activity when tested against avariety of microorganisms, including Staphylococcus aureus and Candida albicans[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Malabaricone B (100 mg/kg; p.o; alternate day, 23 days) inhibits lung tumor (xenograft) growth in SCID mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

342.43

Formula

C21H26O4

CAS No.
SMILES

O=C(C1=C(O)C=CC=C1O)CCCCCCCCC2=CC=C(O)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

References

Purity: ≥99.0%

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Malabaricone B
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