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Cat. No.: HY-N19855

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Merulinic acid

Name: Merulinic acid
Brand: MedChemExpress
SKU: HY-N19855
Availability: PreOrder

(Synonyms: Geranicardic acid)

Merulinic acid (Geranicardic acid) is an acetylcholinesterase (AChE) inhibitor with an IC₅₀ >94 μM against electric eel-derived AChE. Merulinic acid can be used for the research of alzheimer’s disease.

For research use only. We do not sell to patients.

CAS No.: 69506-63-4
Formula: C₂₄H₃₈O₃
Molecular Weight:374.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Merulinic acid Chemical Structure

CAS No.: 69506-63-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

electric eel AChE

>94 μM (IC₅₀)

All Cholinesterase (ChE) Isoforms :

AChE
BChE

In Vitro

Merulinic acid (8-94 μM; 5 min) inhibits the activity of purified AChE from Electrophorus electricus by a maximum of 40%, with an IC₅₀ value >94 μM^[1].
Merulinic acid (20-213 μM; 10 min) induces conformational changes in purified AChE from Electrophorus electricus, decreasing the intrinsic tryptophan fluorescence F/F₀ ratio by approximately 80% at concentrations up to 213 μM, without shifting the fluorescence emission maximum^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 69506-63-4
Molecular Weight 374.56
Formula C₂₄H₃₈O₃
SMILES

CCCCCCCC/C=C\CCCCCCCC1=C(C(O)=CC=C1)C(O)=O
Synonyms

Geranicardic acid
Structure Classification
- Antibiotics
Initial Source
- Microorganisms
Merulius tremellosus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Stasiuk M, et al. Phenolic lipids affect the activity and conformation of acetylcholinesterase from Electrophorus electricus (Electric eel). Nutrients. 2014;6(5):1823-1831. Published 2014 Apr 30. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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