1. Epigenetics
  2. Histone Acetyltransferase
  3. Butyrolactone 3

Butyrolactone 3 

Cat. No.: HY-129039 Purity: >98.0%
Handling Instructions

Butyrolactone 3 is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 shows weak inhibitory on CBP (IC50=0.5 mM)

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Butyrolactone 3 Chemical Structure

Butyrolactone 3 Chemical Structure

CAS No. : 778649-18-6

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Description

Butyrolactone 3 is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 shows weak inhibitory on CBP (IC50=0.5 mM)[1]

IC50 & Target[1]

GCN5

100 μM (IC50)

Molecular Weight

184.19

Formula

C₉H₁₂O₄

CAS No.

778649-18-6

SMILES

O=C([[email protected]@H](C1=C)[[email protected]@H](CCC)OC1=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: >98.0%

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Keywords:

Butyrolactone 3Butyrolactone3Butyrolactone-3Histone AcetyltransferaseHATsHATGcn5histone acetyltransferase,Inhibitorinhibitorinhibit

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