1. Epigenetics
  2. Histone Acetyltransferase
  3. PF-9363

PF-9363 (Synonyms: CTx-648)

Cat. No.: HY-132283
Handling Instructions

PF-9363 (CTx-648) is a first-in-class potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.

For research use only. We do not sell to patients.

PF-9363 Chemical Structure

PF-9363 Chemical Structure

CAS No. : 2569009-58-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 275 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 400 In-stock
Estimated Time of Arrival: December 31
25 mg USD 850 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1350 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

PF-9363 (CTx-648) is a first-in-class potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer[1][2].

IC50 & Target

KAT6A/KAT6B[1]

In Vitro

PF-9363 (0~1 μM; 1 day; ZR75-1, T47D and MCF7 cells) down-regulates the expression of H3K23Ac biomarker[1].
PF-9363 leads to down regulation of a specific set of genes involved in ESR1 pathway, cell cycle and stem cell pathways. PF-9363 shows that the IC50 values for ZR75-1 and T47D are 0.3 nM and 0.9 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: ZR75-1, T47D and MCF7 cells
Concentration: 0~1 μM
Incubation Time: 1 day
Result: Down-regulated the expression of H3K23Ac biomarker.
In Vivo

PF-9363 shows strong anti-tumor activity in patient-derived xenograft models[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

444.46

Formula

C₂₀H₂₀N₄O₆S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References
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PF-9363
Cat. No.:
HY-132283
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