778649-18-6
Chemical Structure
Butyrolactone 3
Synonym(s): MB-3
- CAS No.: 778649-18-6
- Formula:C9H12O4
- Molecular Weight:184.19
IUPAC Name: (2R,3S)-4-methylene-5-oxo-2-propyltetrahydrofuran-3-carboxylic acid
InChIKey: SRQUTZJZABSZRQ-RQJHMYQMSA-N
SMILES: O=C([C@@H](C1=C)[C@@H](CCC)OC1=O)O
Biological Activity: Butyrolactone 3 (MB-3) is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 shows weak inhibitory on CBP (IC50=0.5 mM). Butyrolactone 3 can be used in studies of cancer, metabolic, autoimmune and neurological diseases[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Butyrolactone 3 | 99.58% | Butyrolactone 3 (MB-3) is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 shows weak inhibitory on CBP (IC50=0.5 mM). Butyrolactone 3 can be used in studies of cancer, metabolic, autoimmune and neurological diseases. | ||||||||||||||||||||
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- [1]. Biel M,et al. Design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase Gcn5.Angew Chem Int Ed Engl. 2004 Jul 26;43(30):3974-6 [Content Brief]
- [2]. Haque ME, et al. The GCN5: its biological functions and therapeutic potentials. Clin Sci (Lond). 2021 Jan 15;135(1):231-257. [Content Brief]
- [3]. Holmlund T, et al. GCN5 acetylates and regulates the stability of the oncoprotein E2A-PBX1 in acute lymphoblastic leukemia. Leukemia. 2013 Mar;27(3):578-85. [Content Brief]
Keywords
