1. Metabolic Enzyme/Protease
    Anti-infection
  2. Phosphodiesterase (PDE)
    Parasite
  3. NPD-001

NPD-001 

Cat. No.: HY-136637
Handling Instructions

NPD-001 is a potent Trypanosoma brucei phosphodiesterases TbrPDEB1 and TbrPDEB2 inhibitor, with IC50 values of 4 and 3 nM, respectively. NPD-001 also inhibits human PDEs (phosphodiesterases). NPD-001 shows good anti trypanosomal activity, with an IC50 of 80 nM.

For research use only. We do not sell to patients.

NPD-001 Chemical Structure

NPD-001 Chemical Structure

CAS No. : 469863-16-9

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Description

NPD-001 is a potent Trypanosoma brucei phosphodiesterases TbrPDEB1 and TbrPDEB2 inhibitor, with IC50 values of 4 and 3 nM, respectively. NPD-001 also inhibits human PDEs (phosphodiesterases). NPD-001 shows good anti trypanosomal activity, with an IC50 of 80 nM[1].

IC50 & Target

IC50: 3 nM (TbrPDEB2), 4 nM (TbrPDEB1)[1]

Molecular Weight

584.71

Formula

C33H40N6O4

CAS No.
SMILES

O=C1N(C2CCCCCC2)N=C(C3=CC=C(OC)C(OCCCCOC4=CC=C(C5=NN=NN5)C=C4)=C3)[[email protected]@]6([H])CC=CC[[email protected]@]16[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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