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  3. Sanggenon C

Sanggenon C 

Cat. No.: HY-N0617
Handling Instructions

Sanggenon C is a flavanone Diels-Alder adduct compound, which is isolated from the root bark of Morus cathayana. Sanggenon C exerts protective effects against cardiac hypertrophy and fibrosis via suppression of the calcineurin/NFAT2 pathway. Sanggenon C inhibits inducible nitric oxide synthase expression in RAW264.7 cells, and tumor necrosis factor-α-stimulated cell adhesion and vascular cell adhesion molecule-1 expression, by suppressing NF-κB activity. Sanggenon C possesses antioxidant, anti-inflammatory activities and inhibits Pancreatic lipase (PL) with the an IC50 of 3.00 μM.

For research use only. We do not sell to patients.

Sanggenon C Chemical Structure

Sanggenon C Chemical Structure

CAS No. : 80651-76-9

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Description

Sanggenon C is a flavanone Diels-Alder adduct compound, which is isolated from the root bark of Morus cathayana. Sanggenon C exerts protective effects against cardiac hypertrophy and fibrosis via suppression of the calcineurin/NFAT2 pathway. Sanggenon C inhibits inducible nitric oxide synthase expression in RAW264.7 cells, and tumor necrosis factor-α-stimulated cell adhesion and vascular cell adhesion molecule-1 expression, by suppressing NF-κB activity[1]. Sanggenon C possesses antioxidant, anti-inflammatory activities and inhibits Pancreatic lipase (PL) with the an IC50 of 3.00 μM[2].

IC50 & Target[1]

NF-κB

 

Molecular Weight

708.71

Formula

C₄₀H₃₆O₁₂

CAS No.

80651-76-9

SMILES

C/C(C)=C/C[[email protected]](C1=CC=C(O)C=C1O2)(OC3=CC(O)=C([[email protected]@H](C=C(C)C[[email protected]@H]4C(C=CC(O)=C5)=C5O)[[email protected]@H]4C(C(C=CC(O)=C6)=C6O)=O)C(O)=C3C7=O)[[email protected]]27O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (141.10 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4110 mL 7.0551 mL 14.1101 mL
5 mM 0.2822 mL 1.4110 mL 2.8220 mL
10 mM 0.1411 mL 0.7055 mL 1.4110 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.53 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Sanggenon CNF-κBNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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Sanggenon C
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