Cat. No.: HY-N0617

Sanggenon C

3 Cited Publications

Customer Review

Based on 3 publication(s) in Google Scholar

Sanggenon C, a flavonoid, exerts protective effects against cardiac hypertrophy and fibrosis via suppression of the calcineurin/NFAT2 pathway. Sanggenon C inhibits mitochondrial fission to induce apoptosis by blocking the ERK signaling pathway. Sanggenon C inhibits inducible nitric oxide synthase expression in RAW264.7 cells, and TNF-α-stimulated cell adhesion and VCAM-1 expression, by suppressing NF-κB activity. Sanggenon C possesses antioxidant, anti-inflammatory and antitumor activities.

For research use only. We do not sell to patients.

Purity: 98.46%
CAS No.: 80651-76-9
Formula: C₄₀H₃₆O₁₂
Molecular Weight:708.71

Storage:

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Sanggenon C Chemical Structure

CAS No.: 80651-76-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]^[2]

NF-κB

ERK

All ERK Isoforms :

All NF-κB Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Calu-3	CC₅₀	23.6 μM Compound: 12	Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability	[PMID: 36651644]
Hep 3B2	IC₅₀	1.26 μM Compound: 8	Inhibition of hypoxia-induced HIF1alpha protein accumulation in human Hep3B cells treated for 30 mins measured after 12 hrs by Western blot analysis Inhibition of hypoxia-induced HIF1alpha protein accumulation in human Hep3B cells treated for 30 mins measured after 12 hrs by Western blot analysis	[PMID: 19072214]
Hep 3B2	IC₅₀	3.2 μM Compound: 8	Inhibition of hypoxia-induced VEGF protein secretion in human Hep3B cells after 16 hrs by ELISA Inhibition of hypoxia-induced VEGF protein secretion in human Hep3B cells after 16 hrs by ELISA	[PMID: 19072214]
Hep 3B2	IC₅₀	8.26 μM Compound: 8	Inhibition of hypoxia-induced HIF1 activation in human Hep3B cells by pGL3-HRE-luciferase reporter gene assay Inhibition of hypoxia-induced HIF1 activation in human Hep3B cells by pGL3-HRE-luciferase reporter gene assay	[PMID: 19072214]
HSC-2	CC₅₀	18 μM Compound: 7	Cytotoxicity against human HSC2 cells Cytotoxicity against human HSC2 cells	[PMID: 11429996]
Platelet	IC₅₀	11.2 x 10^-5 M Compound: sanggenon C	Inhibition of 12-hydroxy-5,8,10-heptadecatrienoic acid formation in Wistar King platelets Inhibition of 12-hydroxy-5,8,10-heptadecatrienoic acid formation in Wistar King platelets	[PMID: 3097265]
Platelet	IC₅₀	18 x 10^-5 M Compound: sanggenon C	Inhibition of thromboxane B2 formation in Wistar King platelets Inhibition of thromboxane B2 formation in Wistar King platelets	[PMID: 3097265]

In Vitro

Sanggenon C (4-12 μM; 24 h) inhibits the proliferation of human gastric cancer (GC) cells and greatly reduces the number of GC cell colonies formed^[2].
Sanggenon C (6-10 μM; 24 h) inhibits cell cycle arrest and apoptosis of GC cells^[2].
Sanggenon C (6-10 μM; 24 h) markedly downregulates the levels of p-ERK^[2].
Sanggenon C (6-10 μM; 24 h) induces mitochondrial dysfunction of GC cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[2]

Cell Line:

Human GC cell lines HGC-27 and AGS cells
Concentration:

4-12 μM
Incubation Time:

24 h
Result:

Inhibited the proliferation of GC cells in a dose-dependent manner.
The IC₅₀ values of were 9.129 μM for HGC-27 and 9.863 μM for AGS.

Cell Cycle Analysis^[2]

Cell Line:

Human GC cell lines HGC-27 and AGS cells
Concentration:

6, 8, 10 μM
Incubation Time:

24 h
Result:

The proportions of cells in the G0-G1 phase were increased and the levels of CDK4 and cyclin D1 were decreased.

Apoptosis Analysis^[2]

Cell Line:

Human GC cell lines HGC-27 and AGS cells
Concentration:

6, 8, 10 μM
Incubation Time:

24 h
Result:

Exhibited a dose-dependent induction of apoptosis, with the percentage of apoptotic cells increasing from 7.3% to 24.8% and from 4.6% to 15.1% for HGC-27 and AGS cells, respectively.

Western Blot Analysis^[2]

Cell Line:

Human GC cell lines HGC-27 and AGS cells
Concentration:

6, 8, 10 μM
Incubation Time:

24 h
Result:

The levels of p-ERK were markedly downregulated.

In Vivo

Sanggenon C (10, 20 mg/kg/day; Intraperitoneally; for 3 weeks) improves impaired cardiac function following aortic banding (AB). Sanggenon C protects against cardiac hypertrophy^[1].
Sanggenon C (10, 20 mg/kg/day; Intraperitoneally; for 21 days) suppresses the tumor burden in the nude mice bearing tumor xenografts derived from AGS. Sanggenon C downregulates levels of p-ERK expression^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male C57/BL6 mice (weight 23.5-27.5 g; age, 8 weeks)^[1]
Dosage:

10, 20 mg/kg
Administration:

Intraperitoneally; daily; for 3 weeks
Result:

Prevented the development of ventricular dysfunction, as evidenced by decreased LV end-diastolic diameter, LV end-systolic diameter, and increased LVFS and LVEF.

Chemical Information

CAS No. 80651-76-9
Appearance Solid
Molecular Weight 708.71
Formula C₄₀H₃₆O₁₂
Color Light yellow to green yellow
SMILES

C/C(C)=C/C[C@](C1=CC=C(O)C=C1O2)(OC3=CC(O)=C([C@@H](C=C(C)C[C@@H]4C(C=CC(O)=C5)=C5O)[C@@H]4C(C(C=CC(O)=C6)=C6O)=O)C(O)=C3C7=O)[C@]27O
Structure Classification
- Flavonoids
- Flavanonols
- Phenols
- Polyphenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (3)

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Journal Impact Factor

Talanta

A targeted strategy for screening bioactive inhibitors from Morus alba L.: Immobilized PTP1B affinity chromatography. [Abstract]

2026 Sep 1:307:129772. PMID: 41955787
J Nat Prod

Sanggenon C Suppresses Tumorigenesis of Gastric Cancer by Blocking ERK-Drp1-Mediated Mitochondrial Fission. [Abstract]

2022 Oct 28;85(10):2351-2362. PMID: 36256535

Sanggenon C purchased from MedChemExpress. Usage Cited in: J Nat Prod. 2022 Oct 28;85(10):2351-2362. [Abstract]

Sanggenon C (0, 6, 8, 10 µM) decreases the levels of CDK4 and cyclin D1 in HGC-27 cells.

Sanggenon C purchased from MedChemExpress. Usage Cited in: J Nat Prod. 2022 Oct 28;85(10):2351-2362. [Abstract]

Sanggenon C (6, 8, 10 µM) induces an increase in apoptosis markers in HGC-27 and AGS cells.
Trop J Pharm Res

2023 Aug 31; 22(8):1553-1559.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (141.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.4110 mL

7.0551 mL

14.1101 mL

5 mM

0.2822 mL

1.4110 mL

2.8220 mL

10 mM

0.1411 mL

0.7055 mL

1.4110 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (3.53 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xiao L, et al. Sanggenon C protects against pressure overload induced cardiac hypertrophy via the calcineurin/NFAT2 pathway. Mol Med Rep. 2017 Oct;16(4):5338-5346. [Content Brief]

[2]. Xiao-Jie Chen, et al. Sanggenon C Suppresses Tumorigenesis of Gastric Cancer by Blocking ERK-Drp1-Mediated Mitochondrial Fission. J Nat Prod. 2022 Oct 28;85(10):2351-2362. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.4110 mL	7.0551 mL	14.1101 mL	35.2754 mL
	5 mM	0.2822 mL	1.4110 mL	2.8220 mL	7.0551 mL
	10 mM	0.1411 mL	0.7055 mL	1.4110 mL	3.5275 mL
	15 mM	0.0941 mL	0.4703 mL	0.9407 mL	2.3517 mL
	20 mM	0.0706 mL	0.3528 mL	0.7055 mL	1.7638 mL
	25 mM	0.0564 mL	0.2822 mL	0.5644 mL	1.4110 mL
	30 mM	0.0470 mL	0.2352 mL	0.4703 mL	1.1758 mL
	40 mM	0.0353 mL	0.1764 mL	0.3528 mL	0.8819 mL
	50 mM	0.0282 mL	0.1411 mL	0.2822 mL	0.7055 mL
	60 mM	0.0235 mL	0.1176 mL	0.2352 mL	0.5879 mL
	80 mM	0.0176 mL	0.0882 mL	0.1764 mL	0.4409 mL
	100 mM	0.0141 mL	0.0706 mL	0.1411 mL	0.3528 mL

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Sanggenon C

Apoptosis Compound Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

MAPK Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

Stem Cell Signaling Compound Library

Natural Product Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Differentiation Inducing Compound Library

Reprogramming Compound Library

Oxygen Sensing Compound Library

Anti-Cardiovascular Disease Compound Library

Phenols Library

Pyroptosis Compound Library

Glutamine Metabolism Compound Library

Traditional Chinese Medicine Active Compound Library

Flavonoids Library

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Phosphatase Inhibitor Library

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Anti-Obesity Compound Library

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Pain-Related Compound Library

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Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

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PBCRBS Traditional Chinese Medicine Compound Library

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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

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Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

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Posttranslational Modification Library

Natural Product Diversity Scaffold Library

Lactylation Compound Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) Sanggenon C

All ERK Isoforms

All NF-κB Isoforms

Biological Activity

Chemical Information

Publications (3)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Sanggenon C Related Classifications

HY-N0617 Related Classifications