EGCG-4″-sulfate
EGCG-4″-sulfate is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-)-Epigallocatechin Gallate sulfate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. EGCG-4″-sulfate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma.
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- CAS No.: 2708237-76-5
- Formule: C22H18O14S
- Masse moléculaire:538.43
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
In Vitro
EGCG-4″-sulfate (10-60 μM) inhibits the growth of FB-2 and WRO cells in a dose-dependent manner[1]. EGCG-4″-sulfate (10-60 μM, 0-24 h) reduces cyclin D1 and phosphorylation of AKT and ERK1/2, and increases p21 and p53 expression[1]. EGCG-4″-sulfate (10-60 μM, 12 h) reduces cell motility and migration[1]. EGCG-4″-sulfate (0-20 μM, 0-20 min approximately) inhibits GLUD1/2 and IDH1 activity in a concentration and time-dependent way (biochemical assays)[2]. EGCG-4″-sulfate (0-35 μg/mL, 24-72 h) inhibits the proliferation of colorectal cancer cells (LoVo, SW480, HT-29, HCT-8 cells), increases cell apoptosis and blocks cells at the G0/G1 phase[3]. EGCG-4″-sulfate (30 μM, 3-24 h) suppresses the expression of COX-2 and mPGES-1 mRNAs, prostaglandin E2 production in LPS-induced osteoblasts[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:FB-2 and WRO cells (serum-starved for 48h)
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Concentration:10, 40, 60 μM.
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Incubation Time:4 days
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Result:Inhibited basal cell proliferation (40% in FB-2 and 35% in WRO) at 10 μM, inhibited cell number (by 68% to 73%) at 40 and 60 μM).
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Cell Line:FB-2 cells
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Concentration:10, 40, 60 μM.
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Incubation Time:24 h
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Result:Reduced cyclin D1 level, phosphorylation of AKT and ERK1/2. Induced the expression of p21 and p53, and E-cadherin, N-cadherin, Vimentin and α5-integrin.
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Cell Line:FB-2 and WRO cells (serum-starved for 48h)
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Concentration:10, 40, 60 μM.
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Incubation Time:12 h
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Result:Reduced migration activity in FB-2 and WRO cells.
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Cell Line:Mouse primary osteoblasts (1 ng/ml LPS-treated)
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Concentration:30 μM
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Incubation Time:3, 6, 12, 24 h
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Result:Suppressed the LPS-induced expression of COX-2 and mPGES-1 mRNAs, prostaglandin E2 production.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Orthotopic transplant BALB/c nude mice model[3]
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Dosage:5, 10, and 20 mg/kg, once daily for 14 days.
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Administration:Intragastrical administration.
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Result:Inhibited tumors growth with no liver or lung metastases.
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Animal Model:Model of experimental periodontitis, LPS (25 μg/mouse)[4]
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Dosage:0.5 mg/mouse, a single dose.
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Administration:Injected into the mouse lower gingiva
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Result:Inhibited the LPS-induced loss of bone mineral density (BMD) in mice.
Essai clinique
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2708237-76-5
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Masse moléculaire 538.43
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Formule C22H18O14S
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SMILES
OC1=CC([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2OC(C4=CC(O)=C(OS(=O)(O)=O)C(O)=C4)=O)=CC(O)=C1O
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. De Amicis F, et al. Epigallocatechin gallate inhibits growth and Epithelial-to-Mesenchymal Transition in human thyroid carcinoma cell lines. J Cell Physiol. 2013 Apr 1. [Content Brief]
[2]. Peeters TH, et al. Isocitrate dehydrogenase 1-mutated cancers are sensitive to the green tea polyphenol epigallocatechin-3-gallate. Cancer Metab. 2019 May 20;7:4. [Content Brief]
[3]. Jin H, et al. Epigallocatechin gallate inhibits the proliferation of colorectal cancer cells by regulating Notch signaling. Onco Targets Ther. 2013;6:145-53. [Content Brief]
[4]. Tsukasa Tominari, et al; Epigallocatechin gallate (EGCG) suppresses lipopolysaccharide-induced inflammatory bone resorption, and protects against alveolar bone loss in mice. FEBS Open Bio. 2015 Jun 12;5:522-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGCG-4″-sulfate Related Classifications
HY-150526 Related Classifications
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