2. Immunology/Inflammation
  3. STING
  4. STING agonist-8

STING agonist-8 is a potent STING agonist with an EC50 of 27 nM in THP1-Dual KI-hSTING-R232 cells (WO2021239068A1, compound 5-AB).

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (STING agonist-8 dihydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

STING agonist-8 Chemical Structure

STING agonist-8 Chemical Structure

CAS No. : 2745723-90-2

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STING agonist-8 Related Antibodies

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Description

STING agonist-8 is a potent STING agonist with an EC50 of 27 nM in THP1-Dual KI-hSTING-R232 cells (WO2021239068A1, compound 5-AB)[1].

Molecular Weight

798.90

Formula

C41H46N14O4
CAS No.
SMILES

O=C(C1=CC(C)=NN1CC)NC2=NC3=CC(C(N)=O)=CN=C3N2C/C=C/CN4C5=C(OCCCC6CNC6)C=C(C(N)=O)C=C5C7=CN=C(C8=CC(C)=NN8CC)N=C74
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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STING agonist-8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STING agonist-82745723-90-2STING agonist8STING agonist 8STINGStimulator of Interferon GenesTMEM173MITAERISMPYSinnate immunecGAMPinflammatory cytokinesInhibitorinhibitorinhibit

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STING agonist-8
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